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Any thoughts?

Here are my test results back from my Dr today (I am in the UK)

Haemoglobin 11.3 (normal for non pregnant female 12-15)

Red blood cell 3.84 (normal female 4.2-5.4)

Total white cell count 12.2 (normal approx 4-10)

Serum folate 23.2 (normally 5-16)

Serum vitamin B12 260 (normal 200-900)

Serum iron level 1 umol/L (normal 9-30.4 umol/L)

Haematocrit 0.336 (normal 0.36-0.46)

Neutrophil count 9.65 (normal 1.8-7.8)

Monocyte count 1.01 (normal 0-9)

Eosinophil count 0 (normal 0-5)

MCV 87.3 (normal 80-100)

Lymphocyte count 19.3 (normal 18-48)

Serum TSH 3.26 (0.5-4.8)

Platelet count 159 (normal 150-450)

Creatinine 55 (normal 45-90 mmol/L)

Potassium 3.8 (normal 3.8-4.4 mmol/L)

I've been put on ferrous sulphate and told I'm slightly anaemic and to go for a blood test again in 6 weeks. I'm also a Coeliac.
Best Answer
1756321 tn?1547095325
I thought the all the UK labs had changed to the new B12 range already!? O_o Well anyway clearly your lab hasn't. New B12 serum range starts at either 500 or 550 pg/mL. That isn't optimal either. Sublingual B12 recommended ASAP.  Clear issues with malabsorption. This could be due to low stomach acid to inflammation in the gut (if still eating gluten in the diet).  Having concurrent iron and vitamin B12 levels can show up with normal MCV. Folate can rise with B12 deficiency. WBC can be elevated due to anaemia.

TSH is also too high in the range. TSH recommended lab range is 0.3 - 0.3 mU/L however some labs still use higher ranges. That said, over 95% of people with no thyroid disease has a TSH under 2.5 mU/L.

As the link between Celiac disease and Hashimoto's thyroiditis is well documented, it is highly recommended to do a full thyroid work up - TSH, free T4, free T3, thyroid antibodies - thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb).

"It has been shown in studies that the prevalence of celiac disease in patients with autoimmune thyroid disease is 4-15 times greater than that in the general population. Various findings for the prevalence of celiac disease in Hashimoto's thyroiditis have been reported, between 3.3% and 4.8% in adults. According to a 2007 study published in the World Journal of Gastroenterology, patients with Hashimoto's thyroiditis should be screened for celiac disease and patients with known celiac disease should be screened for Hashimoto's thyroiditis." - Celiac Central - Thyroid Disease

I have Hashimoto's thyroiditis and my endo screened for Celiac disease. Thankfully negative. I like gluten. :)
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Avatar universal
No not having injections as apparently a b12 level of 260 is normal in the UK - however I feel a hell of a lot better since taking supplements. Still very tired so possibly still somewhat anaemic - will find out in two weeks when have a CBC done.
Helpful - 0
1756321 tn?1547095325
Vitamin B12 deficiency can affect the methionine synthase pathway allowing methyltetrahydrofolate (most common form of folate) to accumulate in the blood. Are you having B12 injections?
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Avatar universal
Thanks again - well I have done a home ferritin test (hospital blood test is due to be done in 2 weeks now) and apparently my levels are still low. The weird thing is I have also had a private lab  B12 and folate test this week and the results were back today. it looks like the B12 I have been taking has made a difference as my levels have gone from 260 to 695 in a few weeks! And my folate has come down from 23.2 to 12.7. What on earth has been going on here? Is this the methyl trapping thing I've heard of?Why has it changed so radically?
Helpful - 0
1756321 tn?1547095325
As it is clear you have malabsorption issues, vitamin K deficiency is highly suspect; vitamin K is needed for blood clotting. I had poor blood clotting myself but in my case was due to B12 malabsorption due to autoimmune pernicious anaemia.

Your other symptoms are listed under B12 deficiency too but can't rule out other causes due to any number of deficiency states or other medical conditions.  I'd recommend testing for vitamin D if you haven't already as well. Most people with autoimmune diseases have vitamin D deficiency.

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Avatar universal
Hi, thanks for all the info :) Well at the time of the blood test I had a virus on top of everything else which possibly led to the high WBC. I do follow a gluten free diet also. In the UK the cut off for B12 deficiency is 200 :( In around 4 weeks, my Dr has ordered another full blood count for late June but this will not include testing for B12 this time (just anaemia)! It's all a bit of a nightmare really. I'm still on 600mg Ferrous Sulphate a day and I'm taking Timed Release Vitamin B-12 (1000ug) but I don't know if they are doing much. Main symptoms now are still general fatigue (though nothing like before taking iron), irritability occasionally, brain fog, bleeding gums (had these for a long time) and breathlessness with exertion. I have a hospital appt in late June at an ear nose and throat clinic because I wake every morning with blood in my saliva :(
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