No not having injections as apparently a b12 level of 260 is normal in the UK - however I feel a hell of a lot better since taking supplements. Still very tired so possibly still somewhat anaemic - will find out in two weeks when have a CBC done.
Vitamin B12 deficiency can affect the methionine synthase pathway allowing methyltetrahydrofolate (most common form of folate) to accumulate in the blood. Are you having B12 injections?
Thanks again - well I have done a home ferritin test (hospital blood test is due to be done in 2 weeks now) and apparently my levels are still low. The weird thing is I have also had a private lab B12 and folate test this week and the results were back today. it looks like the B12 I have been taking has made a difference as my levels have gone from 260 to 695 in a few weeks! And my folate has come down from 23.2 to 12.7. What on earth has been going on here? Is this the methyl trapping thing I've heard of?Why has it changed so radically?
As it is clear you have malabsorption issues, vitamin K deficiency is highly suspect; vitamin K is needed for blood clotting. I had poor blood clotting myself but in my case was due to B12 malabsorption due to autoimmune pernicious anaemia.
Your other symptoms are listed under B12 deficiency too but can't rule out other causes due to any number of deficiency states or other medical conditions. I'd recommend testing for vitamin D if you haven't already as well. Most people with autoimmune diseases have vitamin D deficiency.
Hi, thanks for all the info :) Well at the time of the blood test I had a virus on top of everything else which possibly led to the high WBC. I do follow a gluten free diet also. In the UK the cut off for B12 deficiency is 200 :( In around 4 weeks, my Dr has ordered another full blood count for late June but this will not include testing for B12 this time (just anaemia)! It's all a bit of a nightmare really. I'm still on 600mg Ferrous Sulphate a day and I'm taking Timed Release Vitamin B-12 (1000ug) but I don't know if they are doing much. Main symptoms now are still general fatigue (though nothing like before taking iron), irritability occasionally, brain fog, bleeding gums (had these for a long time) and breathlessness with exertion. I have a hospital appt in late June at an ear nose and throat clinic because I wake every morning with blood in my saliva :(
TSH is also too high in the range. TSH recommended lab range is 0.3 - 0.3 mU/L however some labs still use higher ranges. That said, over 95% of people with no thyroid disease has a TSH under 2.5 mU/L.
As the link between Celiac disease and Hashimoto's thyroiditis is well documented, it is highly recommended to do a full thyroid work up - TSH, free T4, free T3, thyroid antibodies - thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb).
"It has been shown in studies that the prevalence of celiac disease in patients with autoimmune thyroid disease is 4-15 times greater than that in the general population. Various findings for the prevalence of celiac disease in Hashimoto's thyroiditis have been reported, between 3.3% and 4.8% in adults. According to a 2007 study published in the World Journal of Gastroenterology, patients with Hashimoto's thyroiditis should be screened for celiac disease and patients with known celiac disease should be screened for Hashimoto's thyroiditis." - Celiac Central - Thyroid Disease
I have Hashimoto's thyroiditis and my endo screened for Celiac disease. Thankfully negative. I like gluten. :)