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Brain/Pituitary Tumors Community
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Avatar universal

What does this diagnosis mean?

Hi guys!
First time here, wondering if I can get some help about the condition that unfortunately my niece is dealing with. it's called Brain cancer grade 3, but I post the full note below this email under the signature. My questions are: what did the diagnosis find out? What is her survival chance? what is the most effective therapy for her?
Truly appreciate your help,
Mo

Source of specimen: Brain tumor Gross
Examination: SRF consist of multiple irregular fragments creamy & soft tissues TM: 1.5 * 1 * 1 cm.  SOS: M / 1 E:
Total Microscopic Examination: Sections of brain show neoplastic lesion composed of atypical glial cells with large hyperchromatic and pleomorphic nuclei and high mitotic index in fibrillary background with vascular proliferation.  
IHC: CD3: Negative in tumor cells.  
CD20: Negative in tumor cells.  
GFAP: Positive in tumor cells.  
Diagnosis / Impression: DX: Brain tumor, resection:
-Consistent with anaplastic astrocytoma / WHO grade: 3.

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Avatar universal
Anaplastic astrocytoma is a rare malignant brain tumor which develops from star-shaped cells called astrocytes, which form part of the tissue that protects the nerve cells in the brain and spinal cord. Astrocytomas are classified according to a grading system developed by the World Health Organization (WHO). Grades I or II astrocytomas grow slower and are considered low-grade. Grades III and IV astrocytomas grow faster and are considered high-grade. Anaplastic astrocytomas are grade III.

According to the American Cancer Society, the percentages of patients with an anaplastic astrocytoma who live for 5 years after being diagnosed are:
- 49% for those aged 22 to 44
- 29%  for those aged 45 to 54
- 10%  for those aged 55 to 64
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