Brief history: No family history of breast cancer, but strong history of colon cancer. Breast reduction & lift in June 2004 with staph infection to left breast immediately thereafter, causing hardened area, I discovered change to existing lump in late Aug 2008, followed by indentation in early October 2008. Diagnosed as fat necrosis by 2 biopsies in Nov & Dec 2008, but area I noticed as changed was not biopsied. Follow-up appt on 5/19/09: Ultrasound showed area that had "changed" and Mammo showed new "dense area w/cluster of microcalcifications" according to Radiologist, who then recommended 2 addl. biopsies stating that they may have missed target area in previous biopsies. Went to different surgeon for 2nd opinion. Had MRI which "lit up the screen" in the same area as indicated on Ultrasound & Mammo, and showed "increased blood flow to lesion". This corresponds to area of change I originally felt. Given all of this, what is the likelihood that this is a malignant lesion and if not, what else could it be?