tamoxifen and provera?

[robin240]

In may last year I had mastectomy for widespread dcis, cells were 100% ER and PR positive, but weakly ER positive and strongly PR positive (I hope I am translating this correctly), and I started taking tamoxifen in august. Before I started the tamoxifen a suspect endometrial polyp showed on the ultrasound. I had the polyp removed three weeks ago and have now been diagnosed with simple endometrial hyperplasia. I am supposed to take provera for 4 months (then have a D & C).

I am aware that provera is contraindicated in case of hormone-driven breast cancer, but was wondering whether the fact that I am taking tamoxifen as prevention and the fact that provera is given for four months make any difference?

I am also wondering if I will have to choose between what cancer to try and prevent, that of the womb or that of the (other) breast?

I am 36 and at the moment do not consider hysterectomy an option.

Thanks,
Robin


Thank you.

[robin240]

Thank you very much for your advice.
Best,
robin

[Fernando Roque, MD]

Hi.  If you're only going to take the provera for 4 months maximum, I don't think it's going to have any adverse effect on your breast, for as long as you continue taking the tamoxifen.