Digestion and Humira

[Robinhoodsecret]

I have had Crohns since 1989 and have a Colostomy along with diarrhea.  My gastro is going to start me on Humira and my question is, does Humira aid with digestion and stop the diarrhea.
Thanks!

[gymdandee]

My wife has been on Humira for about 4-5 months and it hasn't helped! she just had a blood test and her inflammation is very high. her Gastro. Dr. wants to see her in another month and take another blood test. Have you an opinion on the drug  Naltrexone and vedolizumab.
Thanks

[Dr. Kokil Mathur]

Hi!
Yes, Humira will indirectly help in controlling diarrhea and digestion. Let me explain this. Humira or adalimumab is a biological response modifier and tumor necrosis factor (TNF) blocker. Thus, in Crohn’s it will modify your body’s response to disease (bloating, tenderness, diarrhea, indigestion etc). This is because any immune mediated disease like Crohn’s produces excess of an inflammatory protein called TNF-alpha, which causes cellular damage along with pain and inflammation. Humira blocks the action of TNF. Thus once the cellular damage heals, and the inflammation subsides, the diarrhea will subside and the digestion will be better. Please also discuss this with your doctor. Take care!

The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.