Hi. I am taking 100mg of Zoloft for mild depression and irritability. I had loved it apart from the sexual side effects. Wish to God there was an SSRI without those side effects. I had been feeling happier, more focused, and even had more energy. But... in the past month I have been increasingly angry. Wondering if anyone experiences the drug wearing off throughout the day. Seems like I get irritable at night. Thanks for your input.