I was given a prescription for Zoloft a few weeks ago and just started taking it yesterday. I also have a prescription for Buproprion and starting taking that again as well. I thought that buproprion would help me keep my sex drive but, the Zoloft has already started to kill it. I also feel very weird. I feel kind of anxious and like I'm falling back into a very depressed state. When I take the buproprion by it self I usually feel very anxious but, when I take it with other SSRIs I feel more balanced. Like when I took it with Paxill. Has anyone out there had any problems with Zoloft as far as anxiety issues? I've accepted that almost all antidepressants will kill my sex drive so I accept that. I'll try it by itself without the buproprion and see if maybe that's what's making me feel so weird but, I have pretty bad anxiety too and take 1mg of clonezepam daily and my doctor told me that Zoloft will help with anxiety. I just started at 25mg daily of zoloft and after 4 weeks I'm supposed to have worked up to 100mg. Just trying to get some Ideas. Could it just be the Buproprion that's causing all the bad effects?