Whatever gets you through the day, but don't overdue NSAIDS. They all have side effects, and you will absorb some of it into your body. But for occasional use, it's not going to be a problem.
This is basically an NSAID, a lot like aspirin. It's hard to see how rubbing aspirin on your forehead is going to do much. The only proven use for this product appears to be pain in the knees from osteoarthritis. You might want to explain what you mean by decadent arteries and veins in your skull -- this doesn't sound like accurate physiology. If this is indeed caused by the increased circulation from running, it appears your blood vessels are working too well up there, as the blood seems to be rushing there and producing pressure. This is what happens in a migraine, although you're not describing anything like a migraine. So I'm thinking, either you're overdoing it, or you might just try a cold compress.