Antithyroid antibodies and Misscarriages

[ab10]

I have had 3 miscarriages. All at around 6 weeks. 2 after seeing the heartbeat. I have performed all tests possible and all came negative except 1 where my antithyroid antibody was positive (91) but my TSH,T3 and T4 normal.
I am worried the antibody could be the cause. If yes, I am planning to get pregnant. what medicine should I take? and will it be safe for the baby?
I am desperate not to have another miscarriage. Need your help urgently as planning on pregnancy soon.
I was put on prednisolone for 5 weeks and now my antibody level normal. I am planning to stop the steroid. Will the level get high again. Should I take any other medication to keep level low?

[ab10]

Thank you so much for you reply

Here sre some of my results:

ANTI-THYROGLOBULIN ANTIBODIES - 41.10    (Ref range:  60 (Positive))

ANTI-THYROID PEROXIDASE ANTIBODIES H 95.50  (Ref range 60 (Positive))

ANTI-MULLERIAN HORMONE / MULLERIAN INHIBITING 6.7    (Ref Range 2.0 – 6.8 ng/mL)

This was before I took the prednisolone.

After I took the prednisolon the results are:

ANTITHYROID PEROXIDASE ANTIBODIES 41.00  (Ref Range  60 (Positive)

T3  76.3      ( Ref Range 60.0 181.0ng/dl)
T4 10.3        (Ref Range 4.5 12.6 μg/dl)
TSH 2.23      (Ref Range 0.35 5.50μIU/mL)

Since I have stopped taking the prednisolone as I was getting bad side effects . I am worried that the numbers might increase again.

Do you think Synthroid helps? if yes, what is a good dosage and does it have any side effects?

[Super_sally888]

The latest research (go to Mary Shomon's page) is that women with high antibodies and TSH in the upper half of the reference range (which is probably not really correct) are much more likely to miscarry.

Would make sure your TSH is below 2.  Also can recommend trying the gluten free thing too.  It is sometimes recommended for people with thyroid conditions / fertility problems.

[kris71]

i have antithyroid antibodies - mine are not too high (they were in the 100s but since being on synthroid and cutting out gluten etc, they have gotten much lower and one of them is in the normal range now) Anyway - I just did IVF (after almost 2 years of trying to conceive a 2nd child) and was put on prednisone about 2 weeks prior to transfer and I am currently 7 weeks pregnant. I'm still on the prednisone (dr wants me on until 12 weeks). I heard it is ok for the baby but there is a slight chance of cleft palate. I don't know if the prednisone helped me get pregnant or the IVF bypassed some other issue i had that the dr's couldn't figure out. good luck to you.

[Sherri90049]

Oh and I read something about gluten intolerance contributing to autoimmune thyroid issues. (If you Google gluten/thyroid, you'll see what I mean.) So I gave up gluten myself. Wasn't easy, but I do feel better since. It's worth considering any way. :)

[Sherri90049]

My endocrinologist put me on Synthroid because he said that there have been studies that show it reduces the risk of m/c in people with thyroid antibodies. Do you know what your TSH level is? Two different doctors have told me that the optimal TSH range for TTC is between 1 and 2. So maybe ask your dr about Synthroid. (especially if your TSH is over 2) Even though drs think between 2 and 5 is still normal, it simply isn't. Do you have any hypothyroid symptoms? I'd gotten so used to feeling bad all the time, that when I finally started taking Synthroid, I was shocked to see how much better I felt.

The good news is, even if your doctor refuses to give you Synthroid, there's actually something even better than that (I think) that you don't need a prescription for. Maca root. It's a natural thyroid boosting supplement. Not even a drug, actually a vegetable, or more specifically a root. (like a radish) I take 3,000mg/day (in addition to Synthroid) & it helps SO much w/my thyroid issues. I haven't had the antibodies checked lately, but I bet they're getting better.

Please let me know if I can help at any time. I have had 8 losses in total (one m/c and 7 chem preg's). So I understand how you feel. I'm praying the next one is a keeper. Re: stopping the prednisolone, I'm not sure if your antibodies will go back up. I guess it's possible. Luckily yours are not too high. Mine were 548 at the highest last year. (I think they're 249 now.) I haven't taken steroids to try to help the antibodies, but maybe I should be. I'm supposed to take them for lupus, but I was hoping to avoid it.

I have not yet been able to say exactly what caused all my losses, but since most of mine were at 4-5 weeks, I think it's more of an implantation failure potentially due to reduced blood flow to the uterus. I guess it could be thyroid, as I've only been on Synthroid now for 2 months. Guess we'll see with my next one. (hopefully this month) I hope you never have to have another miscarriage. No woman should ever have to go through it. At least you got the test done and you're aware of the problem. I know you'll get it figured out and treated and be able to carry to term. Best of luck!

[Kricket212]

Make an appt to go to a HIgh Risk Dr called a Perintoligist.  I just found out about them.  I have appt 7.6 after 2 m/c.  This Dr claims she wants to see patients prior to conceiving......good luck