help me please

[Romeny]

I found out that I am a FVL (heterozygous) six months ago after a history of seven unexplained miscarriages all over seven years of marriage. I had two spontaneous pregnancies, four insemination and one in vitro fertilization ( 2 embryos) ,all ended with miscarriage as early as 5 weeks (8 weeks at most). In my eighth pregnancy (miscarried two weeks ago) I had heparin shots twice a day ( clexane 0.2 -2000UI anti-Xa) plus baby aspirin and I lost the fetus in 5 weeks. Was it the appropriate dose or it must be reconsidered? I am 1.63 m high and weigh 60 kg if it is calculated according to weight! I am negative for the following lab tests: (Anti-cadriolipin IgM & IgG / Anti- phospholipid IgM & IgG / ANA & ANF / Lupus Anti coagulant). My INR is (1.1) and PT is 29.8 sec and The prothrombin activity is 88%. I've never developed a clot; the FVL  complications only appeared during pregnancy!

  Shall I try to conceive again? Can you tell me please, what is the appropriate heparin dose that helps me to maintain pregnancy? What if my husband and I have identical HLA test, does that mean the impossibility of having a baby? ( we haven't had this test yet)

I really need an answer please! I'm suffering real depression!

[Heather5]

I also have Factor V Leiden (heterozygote), and I had two miscarriages before I had a successful IVF. The first miscarriage, I wasn't on any blood thinners and went to 8 weeks, when the embryo stopped developing and I had to have a D&C. The second time I got pregnant, I was already on baby aspirin and I was suppose to start Lovenox shots once a heartbeat was detected. Well I started spotting the day of my 6 week appointment, and was cramping by the time I got to the doctor. They did see a heartbeat, and I picked up the lovenox on the way home, but never got to start it, as I miscarried naturally that night.  After that I just wasn't getting pregnant again, so after a year and a half with charting, timed intercourse, and then fertility medication and IUIs, we decided not to waste any more time, so we ended up doing IVF last Spring...and this time, since everything was so well controlled, I was on blood thinners from the very beginning...and it worked! I had a healthy baby girl right before Christmas. I was super nervous the entire time, though.

Since Lovenox stays in your system a lot longer than heparin, I was switched to heparin the last month or so (they don't want blood thinners in your system when you deliver, since there are additional bleeding risks involved), and I was on 5000 IU twice a day. I'm 1.68 and about 55 kg.

I hope things work out for you and that you have a successful, full-term pregnancy next time. Best of luck with everything and let me know if you have any other questions.

[Kricket212]

I have MTHFR & PAI-1.  I took the liberty of taking my blood results to a hemotolgist.  I suggest the same for you & they can tell you what is best for future pregancy.  I am sorry this has happend to you.