Histamine is a neurotransmitter that signifies your body to drink water, and triggers the inflammatory response. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. You may drink more water. Maybe you eat untolerable food too often, such as wheat, milk, or others but you don't know about it. You may not sleep well to allow production of more serotonin which antagonise histamine.
You may want to check and see if there is any form of celiac disease in your family. Many of the symptoms you're describing could be attributed to that.