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please help me with my stomach biopsy results !!!!

am suffering from stomach pain since more than five years, I had H. Pylori positive 2 years ago and I took antbiotic and cleared. I have sever pain in my stomach since one month with sometimes little bit of blood when I am vomiting done another endoscopy and the result was as follow:
Cricopharyngius: Normal
Oesophagus: Normal
Cardio-oesophaheal junction normal
Stomach: Erosions. Procedure: Biopsy. Helicobacter Test
Duodenum first part: Normal
Duodenum second part : Normal

finding one small erosion in antrum just superior to the pylorus. Biopsied and clo taken

Biopsy result:
sections show slightly hyperplastic glands and mild nonspecific gastritis. helicobacter pylori is not shown

could  someone please explain what does slightly hyperplastic glands mean????

and what is the best treatment for my condition ??

Thank you
Best Answer
Avatar universal
Hyperplastic means an increase in the number of cells in an area of tissue. I believe the larger majority of glandular cells in the antrum are mucus-secreting cells, but you'd have to check with your doc about that. If the results are mucus-secreting cells, it sounds like your stomach is trying to protect itself from too much acid production. With non-specific gastritis, the doc may suggest a course of acid-suppression meds and a change to a GERD-friendly diet.

But if the hyperplastic cells are gastrin-secreting, further testing might be necessary since gastrin is a hormone that helps to stimulate acid secretion.

At this point, one question to ask is which type of glandular cell was found to be hyperplastic.
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Avatar universal
There are several types of cells in the stomach. Some secrete acid and a substance called intrinsic factor. Others secrete mucus.

The acid is self-explanatory. The intrinsic factor is a protein that binds to the B12 you eat and it takes it through the acid environment to drop it off in the small intestine for 'use.' Without the intrinsic factor a person can end up with anemia.

The mucus cells secrete a substance into the stomach called mucin. It mixes with fluids in the stomach and turns into the 'slimy' substance we know as mucus. This forms a protective layer on the lining of the stomach to coat it against the acid.

The acid is needed to help to break down the food into smaller parts that the rest the enzymes in the small intestine can recognize and work on so that the small, small bits can be absorbed into the body.

The gastrin cells are 'hormone' cells that secrete gastrin. This substance helps to turn on the acid secreting cells. It's necessary, but if too much gastrin is secreted the result can be the production of too much acid. So if gastrin is in too high a level it can create problems.

Not all acid suppression meds work the same for each individual. It's actually a trial-and-error process to find which one will work the best for you.

A fatty liver can be caused by a couple of things. But your doc may suggest you consider changing your diet since that seems to be a major cause of issues in our 'modern' age.
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Avatar universal
thank you for your answer, could you please tell me the different between  the hyperplastic cells are gastrin-secreting and or mucus-secreting cells??
also, I had an ultrasound it shows fattly liver only??
is that related to my stomach pain??
I am on nuxium 80gm at the moment one tablet in the morning and one at night
also I am taken two tablet of zantac. but seems they are not helping. what is the best alternative acid-suppression meds !!

thank you
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