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Avatar universal

Basis for accuracy?

Hi all,

This is more of a conceptual question than anything personal. When we read about a test having 99% accuracy (or to put a finer point on it, 99% specificity), what is going on? In other words, what is the source of error?

Is it just the nature of the given test? If this is the case, would 2 consecutive tests (all other things being equal) bring the specificity to 99.99%?

Or is it the nature of the infection being tested? If this is the case, you wouldn't expect consecutive tests to improve the odds.
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Avatar universal
The reason it's 99% and not 100% is that there is always room for error and nothing is ever truly 100% in science.  And also, as far as false negatives are concerned, there is a window period where infection won't be picked up yet the person is HIV positive.
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Avatar universal
Specificity refers to positive results being true positives.
Sensitivity refers to negative results being true negatives.
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