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How this is possible?

I've heard that 4th gen ELISAs do not detect strain N or O of the virus... How is this possible? What do they have to remain undetectable to the tests? Are they detectable 7 months after the risk?

I also heard that strain N is quite virulent and produces symptoms always (as the patient from France) and a quick conversion to AIDS. Is it true?

Thank you and Happy New Year.
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Avatar universal
You never had a risk.
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186166 tn?1385259382
the duo test is a 4th generation test that does not detect all "groups"
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Avatar universal
The DUO is an ag+ab test.The elisa is just an antibody test.You never had a risk to begin with.You need not be concerned about testing unless you have had a genuine risk.
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But, according to my limited knowleadge, 4th generation ELISA are in fact DUO tests, am I right?
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Avatar universal
Then take a DUO test if you believe this is the case.
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For example, in this link http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007702 it is told that in many cases some ELISA missed to detect the infection for HIV-O.
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Avatar universal
The DUO is a 4th and 5th generation test.
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186166 tn?1385259382
wrong !

all strains but not all groups

The GS HIV Combo Ag/Ab EIA is an enzyme immunoassay kit for the simultaneous qualitative detection of Human Immunodeficiency Virus (HIV) p24 antigen and antibodies to HIV Type 1 (HIV-1 groups M and O) and HIV Type 2 (HIV-2) in human serum or plasma.

The ARCHITECT HIV Ag/Ab Combo assay is a chemiluminescent microparticle immunoassay (CMIA) for the simultaneous qualitative detection of human immunodeficiency virus (HIV) p24
antigen and antibodies to HIV type 1 (HIV-1 group M and group O) and/or type 2 (HIV-2) in human serum and plasma
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Avatar universal
Sure,the source that told me are Hiv specialists in sydney who are considered some of the best specialists in the world.I have never heard of the cases you mention but with the best and most modern tests avaliable to us today I believe what you mention would be a thing of the past.All strains are detected with a 4th generation test.
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Avatar universal
If it's not much to ask, is the source that told you that reliable?

Also, do you think that receiving oral sex without blood or vaginal fluids is a factor risk? Because the experts from that Spanish web I mentioned before told me that it is, although they think that it is low.

Do you think that that I writed before are risk factors I should worry about?

I've read from trustful resources that some brands of ELISA 4th generation didn't detect in France a woman from Cameroon with VIH-O. Does it happen nowadays? Thank you.
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186166 tn?1385259382
justin...

accept your NEGATIVE status and be GREATFUL you did not contract hiv ! ! !

time to move on with your life and stop trolling hiv forums :)
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Avatar universal
YES.
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Avatar universal
And  window period still 3 months for strain O?
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186166 tn?1385259382
4th generation duo will detect O
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Avatar universal
Those subtypes are as rare as hens teeth and are mainly found in West Africa.I have been told that a 4th generation Elisa Antibody will detect every strain of the Hiv virus in any event.
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Avatar universal
???
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Avatar universal
But I mean, ELISA 3rd or 4th generation can detect N and O subtypes? If so, why I read in so many places that they can't? Even a famous web in Spain with experts in this issue told me that subtype N and O can escape detection in ELISAs test, although it is possible its detection in some excepcional cases. What do you think?
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Avatar universal
You had no risk from the above actions. Have your GF test. All modern tests should pick up strains at 3 months.

Rural Africa...Congo and places like that. Not South Africa or more populated places at this time.
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Avatar universal
No, but my ex-girlfriend had had a relationship with an African person, and I think I have had a risk.

First of all, months ago I masturbated her with a finger in which I had a cut, although it was not bleeding, but I don't remember if I had a crust on it or no. Moreover, she said to me that she was on her period, but that she stopped bleeding.

Then she gave me some unprotected fellatios, and I think one time in one of them she brushed her teeth before.

How much risk had I had? I had a negative test in Spain 6 months after this risk by public sanity, but I fear that the test may not detect rare strains as the mentioned before.
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Avatar universal
Are you from rural Africa?
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