There is different chest pain that is associated with MVP than with angina (chest pain...occluded coronary vessels) and following may help you distinquish.
For some insight, Mitral valve prolapse: It is a common heart valve abnormality, affecting 5% to 10% of the population. MVP is especially common among women between 20 to 40 years of age. Chest pain with MVP is usually sharp but not severe. Unlike angina, chest pain with MVP rarely occurs during or after exercise, and usually will not respond to nitroglycerin.
The PFO may not be medically significant and that depends on the degree of shunting. If there is left to right shunting (hole in septum), it merely moves some oxygenated blood to recycle through the lungs again. If there is right to left shunting that would mix blood that should have gone to the lungs. This condition could cause fatique, and if MVP is serious that could lower the heart's output causng fatique as well.
You should contact a doctor to rule out any serious condition and if necessary appropriate treatment.