Plavix and Pantoprazole interaction?

[tony969]

I have been taking Plavix for 3 years after MI back in 2009/100% occlusion of the left ventricle artery/.I have 2 bare metal stents and one DES inside those two in the same artery. Taking Diltiazem, Lisinopril, Aspirin and Ranitidine as well. Have been having constant stomach and chest pains and the doctors are not able to find the cause- at least they don’t think it is a cardiac one./the chest pains/ My gastroenterologist suggested I stop taking Ranitidine and switch to Pantroprazole. I have read a lot about the interaction between Plavix and PPI’s but he thinks only Omeprazole have more effect on Plavix, not Pantoprazole. Please, let me know what your opinion is and have you heard about any interaction between those two? I don’t need an additional heart attack.
Thank you for your response

[phyll50]

I had a heart attack in 2006, and my ulcer was bleeding at the time. I was on Nexium, and had just been switched to Prilosec. When I had the heart attack I had a 100o/o blockage and a 98% blockage and had 2 stents. I still have 6 small blockages so I cannot go off Plavix. My dr. took  me off prilosec and put me on Protonix until my ulcer healed, then I took Pepcid AC 20 mg. He has recently had to put me back on Nexium for severe acid reflux, but told me to take Plavix in the morn. and Nexium at night. Have to have some blood work done in 1 month.

[tony969]

I know...theoretically...in reality..there are studied that shows interraction. Doesn't matter- I am tapering off Pantoprazole and going off it. It seems the GI doctor finally agreed:)

[CCF CCF]

Although there were some studies to suggest an interaction between proton pump inhibitors and plavix on a molecular level, this interaction has not panned out in clinical studies and thus although some physicians may be cautious about prescribing these two medication, there is currently no contraindication to using both of these medications.

[tony969]

I will be very interested in this. Actually there are studies showing zero interraction between Prilosec and Plavix also so it is very difficult to see what this is. Thank you though and please keep me posted.

[jake162]

I have used Pantoprazole and Plavix since 8/2008.  My cardiologist took me off Prilosec due to concerns of interaction with Plavix.  I'm also on aspirin, ramipril, and metoprolol.  

I started having moderate chest pains in Nov/Dec 2012 and my BP spiked to 150/110 max with a 130/90 min.  I had also noticed that my blood was clotting almost instantly after a wound.  I have a cat with claws so blood-letting is common in my home.  In February, my cardiologist refused to renew the prescription for Pantoprazole, so I discontinued use on 2/4/2013.
I use Ranitidine once every 2 or 3 weeks, and found that club soda with my meals virtually eliminates any gastric discomfort.  What is significant, however, is that all chest pain disappeared and my feline-inflicted wounds now take a half hour or more to clot (as I would expect with Plavix and aspirin.)  Additionally, my BP now measures 129/85 max and 90/70 min.  I attribute slow breathing exercises (resperation) for the low min.  I have seen studies (contrary to most) that actually put the Pantoprazole at 39% reduction in Plavix efficacy.  In my layman's opinion, Pantoprazole has (at least, for me) had what I consider a life-threatening interaction with Plavix, and I recommend that everyone re-consider their choice of gastroesophageal meds.  I have an echo scheduled for 2/22 with a cardiologist followup in March.  If there's any interest, I'll keep you posted.

[tony969]

In my case I have two bare metal stents that clogged 3 months later after my heart attack. Then a DES was inserted inside those two bare metal stents which created so called "sandwich" stent...that's why it is kind of dangerous to stop it.