If twice a day is possible, then every 12 hours is best.
I assume you are taking the extended release, mine in "ER". That means one could take a single dose once a day in most cases. But twice is better in my and my cardiologist's mind. So when I was on heavy duty I took 100 morning and 100 night. When I complained about dream problems he said drop the 100 mg at night, just 100 in the morning. I give this data as an example of doctor approved cutting the does in half. I have other examples... but I digress. I'd think if you get two pills in in a 24 hour period that is fine. The closer to 50/50 the better, but not required.
I was taking Metoprolol 100 mg. twice daily but was getting too tired from this so my cardiologist changed it to 50 mg. 4 times a day. I'm still getting the same dose but it is spread out so I'm not having as many side effects from it. It is more of a pain having to take it this way but it does work better for me. So I think there are different ways of taking it but check with your cardiologist first.
thanks for the input everybody :) I'll just try to keep it with the schedule I have been with (12am and 12pm)
so my cardiologist wants me to up my dose from 25mg twice a day to 50mg twice a day. he said that the 25mg was a really small dose and that weaning off would not be a big deal like I asked him because I read everywhere that metoprolol is hard to get off of and he reassured me that it is a small dose, what i didn't ask him this time is if 50mg twice daily is still considered a small dose. is anyone else taking 50mg twice a day?
The lowest does I've ever been on was 50 mg once a day. As said earlier I have been as high as 100 mg twice a day (I did 8 am and 8 pm). I'm now taking 100 mg at 8 am and 50 mg at 8 pm. I found 100 mg didn't bring my HR down low enough, and 200 mg total caused too many side effects.
So, to your question, I do not consider 50 mg twice a day to be a high dose, and I don't see it being so high that you would ever have any problems going off the medication. I have moved from 200 down to 100 down to 50 down to stop/none in a period of a month testing to see if the dose level had any effect on my unpleasant dreaming problems. For the record, the does level didn't seem to be related (guess I just have mental problems) and I suffered no unpleasant sided effects from the changing dose levels.
Metoprolol is a "selective" beta blocker and while it can cause dreaming problems it is less likely too that is a non-selective beta blocker... not something you asked about, just couldn't stop typing :)