Entry inhibitors show promise as drugs

[LilHope2010]

Entry inhibitors like REP9 AC and Myrcludex-B are promising as they are the only drugs that offer a complete CURE for Hepatitis B compared to immune modulators like Pegasys and Anti-virals like Entecavir... I think more research and concentration should be diverted to release inhibitor drugs as they seem to be promising and appropriate....

[StephenCastlecrag]

Thanks for the link. Good to know Mycludex has moved out of the lab and into a clinical trial.

[chanthou]

What about GS 9620. see this link
http://www.hivandhepatitis.com/2011_conference/easl2011/docs/0412_2010_d.html

Can anyone explain in plain English what this means?

[StephenCastlecrag]

It is a drug that modulates our own immune system to fight the virus. Sorry I am not an expert. Think of it as something like interferon.

[stef2011]

that proves drug makers have all the knowledge to stop hbv but take it out only when they fear cure drugs from small companies.this trl activator came out from nothing, absolutely a prove they hide the cures......

our immune system is complitely blind and can t see hbv and respond to it because macrophages are inactivated.being inactivated mean they dont have active receptors to see pathogens in our case hbv

trl7 is activated by this drug and this is one of the main receptors macrophages (or monocites in general) have to detect hbsag

gcmaf activates macrophages that express all receptors after activation so we should get  a better effect from gcmaf, in any case this drug activates trl7 so that hbsag can be detected by our immune system

i think this drug is not potent enough because to clear hbv we need detection and strong immune responce to hbcag, this response will allow clearance of hbsag complitely.strong antihbs antibodies can develop only after strong hbcab antibodies response.

so i guess gcmaf is better than this drug because it activates all macrophages receptors and maybe it will allow to mount a stronger immune response

as to glead releasing ths drug to market...it will only when tenofovir viread patent will expire in 2015.this drug doesn t look potent enough to clear hbv anyway

[4est]

so until now, we have on the pipeline for the next period the flowing drugs:
- REP9 AC
- Myrcludex-B
- GS 9620

something else ?

[LilHope2010]

I have emailed to Himalaya drug company about Liv.52 HB, they say that the Drug Inhibits Antiviral activity and clears Surface Antigen in most patients....Iam not sure how far it is true...