From Epivir to Viread

[Natalie152]

Hi everyone,
I went to see my Dr today and he recommanded to change my medicine to Viread (I am on Epivir more than 2 years). I am wondering if it's necessary to change it now since Epivir works well with me (my DNA is 200 copies). But he was worried about resistance and mutation. Do I have to listen to him? I got Viread today but I am not sure I would start taking it from today.
-Natalie
p.s.: Do you guys drink coffee? I started drinking coffee about 4 months ago...Do you think coffee would make my liver stressed???

[stef2011]

tenofovir works perfectly even if you have lam resistance but it is better to have no resistance since you might develop resistance to tenofovir as well since these are life tx at the moment

check for mutation and start tenofovir immediately, do not wait any day

knowing if you have mutation is important because i would definitely start a combo in this case.Combo can prevent resistance to tenofovir

und means hbvdna undetactable, if hbvdna is 200copies/ml like in your case the tx has failed and resistance can develop quickly

for hbsag seroconversion we have to wait for news from alinia or replicor (both on trial), these are the only meds achieving a very high rate of seroconversion

[Natalie152]

I don't know my old Dr recommended Epivir in 2007. and now I have a new Dr. My new Dr didn't get me tested the mutation. Should I get the mutation test? My new Dr was wondering why my old Dr didn't suggest Interferon in 2007 (Back then, all the numbers were crazy high). Is it too late to change to Viread after mutations started developing?

Thank you all, - Natalie
p.s.: What do you mean by undetectable? It doesn't mean that HBs Ag and HBs Ag are positive, does it?

[stevenNYer]

Taking Epivir for over 2 years put you at very very high risk for developing resistance.  Change to Viread as soon as possible.

But do you know why you were started on treatment?

[stef2011]

take tenofovir as soon as possible, lam is not a tx for hbv anymore if you have 200 copies you probably have resistance already after 2 years you should be absolutely und

check for mutation and if so start combo entecavir+tenofovir and check with other doctors for a combo, after a mutation mono tx is very dangerous

[cajim]

"he was worried about resistance and mutation"

--Did he test you for mutations?  His worry is not without reason because so far Viread presents a better resistance profile than Epivir.

Coffee?

--Some drink, some don't.  Most people don't associate drinking coffee to hurting liver.