If you are in America, then I guess your doctor is Dr Gish.
arc-520, by itself (without other medicines), reduces hbsag by 50% at its peak of effectiveness, for an average hbeag negative person. This is the research data that arrowhead itself presented in Tokyo a month ago.
Once arc-520 is discontinued, hbsag will rebound for most of hbeag negative people, so it is meaningful to use it only in triple combination therapy with pegasys and NUCs, in hope that it will improve chances for hbsag loss. How much these chances will be improved we will see...it maybe that if pegasys will cure a particular genotype by 10%, then the combo with ARC-520 might increase this to 15%...or to max 20%. However, as it is a brand new medicine...we don't have a widely available data of its possible side effects.
again arc has been proven useless to cure hbv, replicor has cured hbv
only replicor works all the rest attempts to disturb replicor and all failed
I wonder who your doctor is. According to Arrowhead, ARC520 is not as effective in HbeAg negative patients than HBeAg positive patients, so they are fast tracking a new ARC521 for HBeAg negative patients. It is still an open question whether the depth of HBsAg reduction by ARC520/521 is sufficient to revive the Immune system to actually clear the infection, also the period of maintained reduction for this to happen is also not clear.
if replicor for some strange reason do not come out to market can one privately purchase it?
What can we do help the replicor company release this drug then?
only replicor has cured patients
none of the drugs on study cured anybody except replicor and peginterferon, dont post things that are not real yet, all of these drugs will be probably a failure except replicor
In May 2015, a Phase 2 clinical trial of GS4774 in HBV patients taking oral antiviral failed to meet its primary endpoint (no significant reduction in HBsAg). It was a very disappointing result and forced the company to lay off staff and re-consider its future. This current trial on patients not receiving treatment is not expected (my opinion) to perform better. Whether Gilead will continue to invest in this therapeutic vaccine is not known.
The "cure" at the moment is entecavir and tenofovir, and for some people pegasys, with TAF about to hit markets soon.
No cure will come to market within next 4-5 years IMO.
So far we only know that Replicor works.