Aa
HBeAg positive to negative
Hi,
I have Hep B for 16 years now (im now 30 years old), receive it from blood donation... Never mind that now. From 2004-2008 i received Lamivudine therapy and my liver enzymes got down to reasonable limits. They stayed there for 5, 6 years until my last blood control. Here is chronological results;
2008: AST 33, ALT 30, ALP 70, GGT 17, UBIL 10
2010: AST 42, ALT 46, ALP 66, GGT 16, UBIL 11
HBsAg pos.>250 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
Anti-HBc IgM neg, HBeAg pos, Anti-HBe pos, HBV-DNA 791 IU/mL
2011: AST 32, ALT 47, ALP 76, GGT 19, UBIL 11
2012: AST 35, ALT 56, ALP 66, GGT 21, UBIL 15
2013: AST 72, ALT 156, ALP 59, GGT 24, UBIL 11
HBsAg pos.9755 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
Anti-HBc IgM neg, HBeAg neg, Anti-HBe pos, HBV-DNA 5.45e+7 IU/mL
From what you can see my HBeAg turned from positive to negative and my liver enzymes and HBV-DNA started to raise.....
I'm waiting for specialist check in a few week but want some advices or opinions from any experiences, maybe...
Thank you all in advance..
I have Hep B for 16 years now (im now 30 years old), receive it from blood donation... Never mind that now. From 2004-2008 i received Lamivudine therapy and my liver enzymes got down to reasonable limits. They stayed there for 5, 6 years until my last blood control. Here is chronological results;
2008: AST 33, ALT 30, ALP 70, GGT 17, UBIL 10
2010: AST 42, ALT 46, ALP 66, GGT 16, UBIL 11
HBsAg pos.>250 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
Anti-HBc IgM neg, HBeAg pos, Anti-HBe pos, HBV-DNA 791 IU/mL
2011: AST 32, ALT 47, ALP 76, GGT 19, UBIL 11
2012: AST 35, ALT 56, ALP 66, GGT 21, UBIL 15
2013: AST 72, ALT 156, ALP 59, GGT 24, UBIL 11
HBsAg pos.9755 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
Anti-HBc IgM neg, HBeAg neg, Anti-HBe pos, HBV-DNA 5.45e+7 IU/mL
From what you can see my HBeAg turned from positive to negative and my liver enzymes and HBV-DNA started to raise.....
I'm waiting for specialist check in a few week but want some advices or opinions from any experiences, maybe...
Thank you all in advance..
i got the drug to take in case of low anc, it is neupogen
so if your anc is 260 it would be best to consider neupogen and bring it back to more than 500 so you can keep therapy at 180mcg
it is very important to keep the 180mcg dose since you had response on hbsag, it would be too bad if you lose response
so if your anc is 260 it would be best to consider neupogen and bring it back to more than 500 so you can keep therapy at 180mcg
it is very important to keep the 180mcg dose since you had response on hbsag, it would be too bad if you lose response
from hcv forum a good thread
http://www.medhelp.org/posts/Hepatitis-C/Low-WBC--RBC--Platelet--should-I-continue-treatment/show/1934195
You can't do anything about any of those numbers. If they get severe enough your doctor might prescribe "rescue" meds that will help, or might suggest reducing the dosage of your ribavirin, but you are not currently near to those levels. Each doctor does things slightly differently, but to give you a better idea of the problem numbers, most do not worry about platelets unless they go below 50 (and then consider Rx Promacta or transfusion), most do not worry about HGB until it goes below 10, and some let it go as low as 8 before taking action (Rx of procrit injections or possibly transfusions), and most do not worry about low WBC unless the ANC drops below 0.5, and then consider dose reduction, Rx Neupogen injections, or stopping tx.
During tx my HGB dropped as low as 10.1, my ANC dropped as low as 0.6 and my platelets dropped as low as 0.51. My doctor ordered more frequent testing (weekly) each time something dropped near to the cutoff line, but each time the numbers bounced back a little on their own without intervention. I completed 48 weeks of tx in Sept 2012, without any rescue meds or dose reductions, and am now SVR.
You can do it, just make sure you have frequent tests whenever the numbers drop very low, as not everyone has them bounce back on their own!
http://www.medhelp.org/posts/Hepatitis-C/Low-WBC--RBC--Platelet--should-I-continue-treatment/show/1934195
You can't do anything about any of those numbers. If they get severe enough your doctor might prescribe "rescue" meds that will help, or might suggest reducing the dosage of your ribavirin, but you are not currently near to those levels. Each doctor does things slightly differently, but to give you a better idea of the problem numbers, most do not worry about platelets unless they go below 50 (and then consider Rx Promacta or transfusion), most do not worry about HGB until it goes below 10, and some let it go as low as 8 before taking action (Rx of procrit injections or possibly transfusions), and most do not worry about low WBC unless the ANC drops below 0.5, and then consider dose reduction, Rx Neupogen injections, or stopping tx.
During tx my HGB dropped as low as 10.1, my ANC dropped as low as 0.6 and my platelets dropped as low as 0.51. My doctor ordered more frequent testing (weekly) each time something dropped near to the cutoff line, but each time the numbers bounced back a little on their own without intervention. I completed 48 weeks of tx in Sept 2012, without any rescue meds or dose reductions, and am now SVR.
You can do it, just make sure you have frequent tests whenever the numbers drop very low, as not everyone has them bounce back on their own!
wbc is low 2.6
try melatonin 20-30mg daily and see if wbc increases.melatonin increases wbc normally, let's see if it still increases wbc under pegintf.melatonin regulates sleep too so take it at night before going to bed, not during the day
neutrophils is low .26
this is low too, take both vit d3 10.000iu daily and liposomal vitamin c, this should boost machrofages function and maybe they will act to increase both wbc and neutrophils.i ll go check on hcv community what they do in your cases
try melatonin 20-30mg daily and see if wbc increases.melatonin increases wbc normally, let's see if it still increases wbc under pegintf.melatonin regulates sleep too so take it at night before going to bed, not during the day
neutrophils is low .26
this is low too, take both vit d3 10.000iu daily and liposomal vitamin c, this should boost machrofages function and maybe they will act to increase both wbc and neutrophils.i ll go check on hcv community what they do in your cases
i just had my cbc today
wbc is low 2.6
platelet is low 54
neutrophils is low .26
anc (absolute neutrohil count) is 676
today i applied dose of 180mcg
wbc is low 2.6
platelet is low 54
neutrophils is low .26
anc (absolute neutrohil count) is 676
today i applied dose of 180mcg
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