HBeAg positive to negative

[bollux]

Hi,

I have Hep B for 16 years now (im now 30 years old), receive it from blood donation... Never mind that now. From 2004-2008 i received Lamivudine therapy and my liver enzymes got down to reasonable limits. They stayed there for 5, 6 years until my last blood control. Here is chronological results;

2008: AST 33, ALT 30, ALP 70, GGT 17, UBIL 10
2010: AST 42, ALT 46, ALP 66, GGT 16, UBIL 11
         HBsAg pos.>250 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
         Anti-HBc IgM neg, HBeAg pos, Anti-HBe pos, HBV-DNA 791 IU/mL
2011: AST 32, ALT 47, ALP 76, GGT 19, UBIL 11
2012: AST 35, ALT 56, ALP 66, GGT 21, UBIL 15
2013: AST 72, ALT 156, ALP 59, GGT 24, UBIL 11
         HBsAg pos.9755 IU/mL, Anti-HBs neg, Anti-Hbc total positive,
         Anti-HBc IgM neg, HBeAg neg, Anti-HBe pos, HBV-DNA 5.45e+7 IU/mL

From what you can see my HBeAg turned from positive to negative and my liver enzymes and HBV-DNA started to raise.....

I'm waiting for specialist check in a few week but want some advices or opinions from any experiences, maybe...

Thank you all in advance..

[stef2011]

use 180 dose, the lower dose dont work, response is low at 180 already

low plts are less than 20.000-25.000, if you have higher it is ok to keep the high dose.expert specialists are able to monitor you at these low plts, the bad ones are not experinced and are scared of any abnormal value

neutrophils can be as low as 0.5, what are your values?

how to keep less sides and higher wbc and plts:
melatonin
vit d3
liposomal vitamin c

if these fails instead of lowering pegintf dose there are drugs that increase plts

[stef2011]

if needed you can post on hcv community about peg sides effects and warning low plts and wbc and drugs used.pegintf has much heavier sides for hcv infection so they are more experienced on this, on hbv sides are milder

[fredz2013]

my last  wbc  is 3.24 si units
platelet is 92
neutrophils 16.70

last dose was 135mcg.
my lowest platelet count drop to 52. No meds administer yet for platelet

[Magda123]

Fred, when you started interferon, how was your hbeag +/-, hbeab+/-?

[stef2011]

plts 52 is not sufficent to lower pegintf dose, you can reach 20-25 or use drugs to increase plts instead of lowering intf dose.135mcg dose has much lower chances of success

these are of course good being on intf whty dont you discuss the dose with your specialist or check with another intf experienced specialist too?

my last  wbc  is 3.24 si units
platelet is 92
neutrophils 16.70

[juanchodiego]

Kumusta experience mo sa Pginterferon??? any side effect experience???