Hepatitis B - Biopsy

[Neil888]

I am 31 year old Indian born male currently residing in US.
I have been diagnosed with Hepatitis B earlier this year (Feb 2013) by a screening test.
I had taken Hepatitis B vaccine back in 2007 before coming to use (3 shots), hence it looks like i got infected before that.

My results are as follows.
Date : March 4, 2013
HBV DNA - 1130 IU/ml
ALT - 30 ( Lab reference rage - 0 to 60)
AST- 24  ( 0 to 40)
HBeAg -Ve, Anti Hbe Positive
Date : April 8, 2013
AFP - Not detectable
Lever Ultrasound : Liver is unremarkable ( Normal result)

The HBV DNA and ALT, AST repated after 3 months.
Date : 3 June 2013
HBV DNA - 2590 IU
ALT - 41 ( lab Normal range 0 to 65)
AST - 26

I am really freaked out since my DNA is higher and ALT is also higher.

I met the doctor this week since I was concerned about elevated HBVDNA and ALT values. I requested doctor to have a liver biopsy. My doctor told me that he is not too much concerned with increased DNA and ALT values. He thinks to wait for next three months (for next set of HBVDNA and AST/ALT Tests) before biopsy, and told me if it remains persistently elevated, we may do biopsy. We do not have Fibroscan machines.

Can you please advise on waiting for biopsy for three months?

Also, My doctor told me that ALT seems normal, I have doubt on that as well. Any thoughts?

I really appreciate you insight.

Regards
Neil

[Neil888]

And again AFP and US every 6 months

[Neil888]

Doctors are telling me that they will observe by doing LFT & Hbvdna every six months and fibroscan every year.

[stef2011]

Based on my test results, and present test limitations, do you agree with their opinion? What should i do at this point of time?

no without hbsag quantity we dont know if you are inactive, we dont know cccdna quantity and number of infected cells in the liver, we also dont know if pegintf can clear your hbv and if you have active immune response.since this test is the most important, which is logic even for the most stupids...the goal is hbsag negative...., you better send your samples to india or europe to check hbsag

[Neil888]

Stef
With normal fibroscan results, my doctors are suggesting that I may be an inactive career and not a candidate for tratment at this point of time. In US we dont have HBSAG quant test available. Based on my test results, and present test limitations, do you agree with their opinion? What should i do at this point of time?
Thanks

[Neil888]

Had fibroscan yesterday. Got liver stiffness of 5.5
Doc told me it is normal. Any thougts?

[stef2011]

perfect liver