No, there should be no concerns. Just continue with your regular dosage. Some patients take 2x0.5mg per day of Entecavir for their treatment (in case of previous experience with Lamivudine).
I am not a doctor.
Is there any problem if im not taking etv 0,5 at same hour? I mean, sometimes i took it 1-2 h earlier, other times 1-3 h later than usual.