You will likely see a small rise in hbv dna when switching to tdf only. These two antivirals have a mildly additive effect when taken together. It is possible that you have some partially adaptive mutation in your hbv genome that explains the less than perfect response. If you have to pay for tdf yourself it would be advisable to buy it from india via internet ordering, you can save more than 70%. i dont have the website handy, but you will find it if you look long enough. I think one of the indian names for tenofovir is tenvir. The indian pharmaceuticals are of the highest quality, you do not need to worry.
Thanks Stef;
I am wondering why my hbvdna goes down so slow.
Now almost 3 years on ETV with the last 6 month of added TDF.
I have already taken ETV one and half more month than the date of blood test that showed 13 IU/ml.
What may possibility happen if I stop taking ETV? Can I start taking it later if I see any rise again in my hbvdna?
it would be best to wait for hbvdna und, you are close to it maybe one more month
hbsag doesn t matter now
Hi everybody:
After being on ETV+TDF combo for 2 months, my HBV DNA reduced to 30 from 70.
Now after 6 months, the number has reduced to 13 iu/ml. My ALT is also 1.5 times of the normal still.
I did Hbsag test and turned out to be 14000 IU
What do you think now. Can I stop taking Entecavir now safely and go only with TDF. I can not afford to have both at the same time.
Regards,
Finally after lots of discussions with my doctor, he agreed to prescribe TDF. From today I am going to TDF+ETV combo. I have to pay for TDF out of my pocket which is expensive almost 610 $. But ETV is covered. Lets see how much difference this combo will make.
I just need Hbsag measurements and need to discuss with my Dr. where we can do it in Canada. not knowing this, I will have no idea when should I start Interferon. I just hope that since my ALT was always high, my hbsag has lowered considerably. we will see.
12.30 nmol/L
extremely low but convert to ng/ml which is the correct unit for vit d.for optimum health and immune system you need 60-90ng/ml (normal range 50-100ng/ml)
2000iu is nothing it wont work if vit d is low due to chronic infections, you need at least 10.000iu daily and then recheck in 4 weeks to see if it has increased or not.you need both vit25oh and calcium test to see if everything is working correctly
which form and brand of vitamin d you suggest?
only vit d3 which is the natural form, puritans is ok because they make 5000iu pills and 10.000iu pills and very cheap
the facts are:
etv failure and partial response in ur case
resistance can be confimed by test only and even if negative it is not sure you have no resistance, test sensibility is poor
why keep entecavir if:
tenofovir is more potent
tenofovir is safer on cancerogenesis
tenofovir has no resistnce
tenofovir costs 50% less than etv or more
this is not to promote tdf use but it is definitely better especially in ur case, i d make add on 6 months and then stop etv