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How to know if Entecavir stopped working
Dear all,
First I have to really thank for all of you who are giving us lots of good information.
I am 33 years old man and I think I have Hep B from birth, because of our family history.
I started taking Entecavir 2 years ago and the reason to start treatment was having 640 milion copy/ml of DNA and ALT more than normal range (almost two times of normal ). So Doctor decided to treat. Almost after a year of taking Entecavir my DNA dropped to 20 copy/ml, but still ALT more than the normal range. Then 6 months later DNA increased to 70 with abnormal ALT and 6 month after that DNA went up to 137 with ALT 70. When I started treatment my Hbeag was positive but after a year it turned to be negative and Hbab get positive.
Now I am a little worried about Entecavir suspecting that maybe virus gets resistance to it because of my DNA increase but doctor telling me that these variations in DNA are ok since it is not too much variations and the most important is that your e-antigen is negative. Yesterday I again tested for DNA test but really I am worried.
Any comments and suggestions will be much appreciated.
Aydin
First I have to really thank for all of you who are giving us lots of good information.
I am 33 years old man and I think I have Hep B from birth, because of our family history.
I started taking Entecavir 2 years ago and the reason to start treatment was having 640 milion copy/ml of DNA and ALT more than normal range (almost two times of normal ). So Doctor decided to treat. Almost after a year of taking Entecavir my DNA dropped to 20 copy/ml, but still ALT more than the normal range. Then 6 months later DNA increased to 70 with abnormal ALT and 6 month after that DNA went up to 137 with ALT 70. When I started treatment my Hbeag was positive but after a year it turned to be negative and Hbab get positive.
Now I am a little worried about Entecavir suspecting that maybe virus gets resistance to it because of my DNA increase but doctor telling me that these variations in DNA are ok since it is not too much variations and the most important is that your e-antigen is negative. Yesterday I again tested for DNA test but really I am worried.
Any comments and suggestions will be much appreciated.
Aydin
Today i got my results regarding vitamin d.
My vitamin d total is 12.30 nmol/L. seems soooo low/ is'nt it?
I was reading your previous posts regarding this, and as far as i understood, i need start taking 1000 Iu per day of vitamin d pills? Am i right? My doctor told me start with 2000 IU?
which form and brand of vitamin d you suggest?
My vitamin d total is 12.30 nmol/L. seems soooo low/ is'nt it?
I was reading your previous posts regarding this, and as far as i understood, i need start taking 1000 Iu per day of vitamin d pills? Am i right? My doctor told me start with 2000 IU?
which form and brand of vitamin d you suggest?
how long have you been on ETV? if more than a year and 1500 IU/Ml, it signals that maybe ETV not working well. In 24 weeks you should be less than 24 IU/Ml in order to say that ETV works
So, I got the answer. He said that there is no reason to panic when the viremy is one month little higher. He said, we will see another result after this month and then we will take a decission. It is little stressing but I still trust him, so, I will see. However, he said that my temporary viremy 1500 UI/ml is very small, no reason to be scared.
It seems I am becoming resistant for ETV too. I am still waiting the answer from my doctor after my last blood test....
That is just great. Why give us antivirals in the first place to create super viruses.
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the facts are:
etv failure and partial response in ur case
resistance can be confimed by test only and even if negative it is not sure you have no resistance, test sensibility is poor
why keep entecavir if:
tenofovir is more potent
tenofovir is safer on cancerogenesis
tenofovir has no resistnce
tenofovir costs 50% less than etv or more
this is not to promote tdf use but it is definitely better especially in ur case, i d make add on 6 months and then stop etv