Aa
I have fibrosis
Dear All,
I have just joined the forum today and I have read many threads already over the last few months. I want to now start taking more care AND control.
My history is that I have had hep b since 1991. I had biopsy then and my liver was fine. The consultant put me on alpha interferon for 6 months but it did no good or so I was told. Over the next few years I was put on lamivudine and then combo with adefovir. In 2007 I was taken off combo and my hbvdna fluctuated between und and 2000/3000. Recently I had a fibroscan which was inconclusive (But showed around 11.7 kpa). I then had a second biopsy whic showed that I have fibrosis between stage 3 and 4. I was immediately put on tdf and have been on it now for a year.Having said all that I feel great and do lots of exercise in the gym 3/ 4 times a week. I can run 10k on treadmill in 55 minutes.
I take a 1500mg krill oil tablet each day; 3x 60mg blueberry extract ;1000mg garlic and 1 selenium ACE.
I have seen what tests needs to be done in other threads here and I intend to get them done soon . I know that I am anti HBE positive but i do not know the (critically important) IU/ML for the surface antigen yet.
Thank you all for the support given to others here and I am now joining those ranks. I just hope my condition is not too bad??
I have just joined the forum today and I have read many threads already over the last few months. I want to now start taking more care AND control.
My history is that I have had hep b since 1991. I had biopsy then and my liver was fine. The consultant put me on alpha interferon for 6 months but it did no good or so I was told. Over the next few years I was put on lamivudine and then combo with adefovir. In 2007 I was taken off combo and my hbvdna fluctuated between und and 2000/3000. Recently I had a fibroscan which was inconclusive (But showed around 11.7 kpa). I then had a second biopsy whic showed that I have fibrosis between stage 3 and 4. I was immediately put on tdf and have been on it now for a year.Having said all that I feel great and do lots of exercise in the gym 3/ 4 times a week. I can run 10k on treadmill in 55 minutes.
I take a 1500mg krill oil tablet each day; 3x 60mg blueberry extract ;1000mg garlic and 1 selenium ACE.
I have seen what tests needs to be done in other threads here and I intend to get them done soon . I know that I am anti HBE positive but i do not know the (critically important) IU/ML for the surface antigen yet.
Thank you all for the support given to others here and I am now joining those ranks. I just hope my condition is not too bad??
This is pretty much the history. I am sure that I was not always DANA und over these years. My doctor never mentioned ALT to me on any occasion except to say my liver functions were always normal. He put me on adefovir to give lamivudine a "holiday". And later he tried both in combo. My DNA def became und during this time becasue I remember him saying. And in 2007 they decided to stop treatment because I guess that I was und for quite some time. Whilst I remained und sometimes it would flare up to the IU levels that I have indicated. But they did not seem to worry about this . It wasnt until I had the fibroscan that further action was taken. I guess I could have gone to tdf in 2007 but it was not offered and I didnt even know that it existed. I go to clinic each month to check creatine levels and next time I go I will ask for ALT at baseline one year ago when I started tdf and will also ask to see what it is now.
Thank you so much for detailing my history and making this effore for me. I tryuly appreciate it.
Thank you so much for detailing my history and making this effore for me. I tryuly appreciate it.
do you have any explanation why aberdeen577 having fibrosis stage 3/4 even he was on antiviral medication? Thank you.
Still have some questions, that can help to figure out what was going on.:
How you discoverd the hbv infection, back to 1991 ? (why you made this tests)
I suspect that you (and you doctor) stop tha Lamivudine and start the Adefovir becuse the HBV DNA was not undetectable.
How was your HVB DNA over the Adefovir period ? And why you decided to add Lamivudine ?
How you where monitorised after stooping the antiviral combo (after 2007) ? (test was only HBV DNA?)
Do you remember when after starting the Tenofovir treatment was the month that you notice HBV DNA to 400 UI ? (was first test ?, or was something like start Tenofovir - HBV DNA - undetectable .... HBV DNA - 400 UI...... HBV DNA - undetectable .... ?)
How you discoverd the hbv infection, back to 1991 ? (why you made this tests)
I suspect that you (and you doctor) stop tha Lamivudine and start the Adefovir becuse the HBV DNA was not undetectable.
How was your HVB DNA over the Adefovir period ? And why you decided to add Lamivudine ?
How you where monitorised after stooping the antiviral combo (after 2007) ? (test was only HBV DNA?)
Do you remember when after starting the Tenofovir treatment was the month that you notice HBV DNA to 400 UI ? (was first test ?, or was something like start Tenofovir - HBV DNA - undetectable .... HBV DNA - 400 UI...... HBV DNA - undetectable .... ?)
you say "During all of this time my ALT was never brought up to me", so that means you don't now your ALT from 1991 until now ?
(maybe you have it under ALAT or GPT or SGPT or Alanine Aminotransferase names)
Anyway I was put in a another form (easy for reading) all your information, please add more information (or correct this ones) is is necessary
1991
- discover the Hbv infection
- First biopsy => F0 (liver was fine)
- Start interferon
- Stop interferon
- ALT - unknown
1992(1993)
- Start Lamivudine
- HVB DNA - low level but not undetectable
- ALT - unknown
2002 (2003)
- Stop Lamivudine and Start Adefovir
- ALT - unknown
2005 (2006)
- Add Lamivudine (combo with Adefovir)
- ALT - unknown
2007
- HVB DNA - undetecatble
- Stop the antiviral combo
- ALT - unknown
2007 - 2011
- HVB fluctuate around 2000 - 3000 UI/ml
- ALT - unknown
2011
- fibroscan inconclusive ( 11.7 kpa)
- second biopsy => F3/4
- Start Tenofovir
- ALT - unknown
2011 - 2012
- HVB DNA - undetectable (except one month that was 400 UI)
- ALT - unknown
(maybe you have it under ALAT or GPT or SGPT or Alanine Aminotransferase names)
Anyway I was put in a another form (easy for reading) all your information, please add more information (or correct this ones) is is necessary
1991
- discover the Hbv infection
- First biopsy => F0 (liver was fine)
- Start interferon
- Stop interferon
- ALT - unknown
1992(1993)
- Start Lamivudine
- HVB DNA - low level but not undetectable
- ALT - unknown
2002 (2003)
- Stop Lamivudine and Start Adefovir
- ALT - unknown
2005 (2006)
- Add Lamivudine (combo with Adefovir)
- ALT - unknown
2007
- HVB DNA - undetecatble
- Stop the antiviral combo
- ALT - unknown
2007 - 2011
- HVB fluctuate around 2000 - 3000 UI/ml
- ALT - unknown
2011
- fibroscan inconclusive ( 11.7 kpa)
- second biopsy => F3/4
- Start Tenofovir
- ALT - unknown
2011 - 2012
- HVB DNA - undetectable (except one month that was 400 UI)
- ALT - unknown
As far as I know fibroscan is the average from the 10 measures (at least this was in my case and I have it twice until now (one year apart)).
I think that they say to you that is to early, because they expect some revers of the fibrosis in one year and not in couple of months, so you can ask for a fibroscan now.
I think that they say to you that is to early, because they expect some revers of the fibrosis in one year and not in couple of months, so you can ask for a fibroscan now.
Your situation is indeed unusual and worrisome. You stated that you do not know any ALT information over the years. I assume that the viral load numbers that you gave are in international units.
The driving force for fibrosis progression is the intensity of the immune response in the liver and more specifically the degree of activation of the stellate cell system.
Normally a low viral load lowers the immune attack on the liver.Thats why antivirals protect the liver health.
Do you have any other risk factors for liver disease like obesity or diabetes or alcohol use or hemochromatosis that could have accelerated the damage?
How frequently was the viral load tested after you came of the antivirals?
The driving force for fibrosis progression is the intensity of the immune response in the liver and more specifically the degree of activation of the stellate cell system.
Normally a low viral load lowers the immune attack on the liver.Thats why antivirals protect the liver health.
Do you have any other risk factors for liver disease like obesity or diabetes or alcohol use or hemochromatosis that could have accelerated the damage?
How frequently was the viral load tested after you came of the antivirals?
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