INF + Tenofovir + Simavastatin

[lagona]

After treating with mono entecavir for 5 years, I decided to switch to tenofovir (Pavtino-B made in India) combo for two months.
And recently I have consulted with my doctor to add on interferon  Pegnano 180mcg/0.5mL made in Vietnam

Now I am on : INF Pegnano + Tenofovir + Vit D3 10.000IU + Simavastatin 40mg

Here is my status HBV

Date : 19/05/2014
HbsAg : 8462 IU/ml
Anti-hbe+ seroconversion year 4th entecavir
GGT : 38
ASAT : 38
ALAT : 29
Creatine : 12 mg/l
HBV DNA : Undectable since 3 months with Entecavir
Fibros scan : 4.3 kpa
Phophatase Alcaline : 156 UI/L
Alpha Foetoproteine : 2.28 ng/ml

After 6 Injections with interferon starting from 03/06/2014, here is the test result 15/07/2014

HbsAg : 7386 IU/ml
Anti-Hbe+
GGT : 75
ASAT : 79
ALAT : 87
Creatine : 12 mg/L
Vitamine D TOtal : 50 ng/ml

I am thinking to increase my dose on Vit D3 to 20.000 IU and Simavastatin to 80mg.

Can you give some advices?

[stef2011]

http://en.wikipedia.org/wiki/Sodium_bicarbonate

if you dont like the taste you can add lemon or maple syrup, it is good to lower acidity (low PH).acidity promotes cancer and makes a lot of work on kidneys that try to balance ph towards alkaline 7
the optimum balance is around 7-7.5 of ph for human body

[lagona]

Thank Stef2011
I will find it when I go back to the city.

[stef2011]

Also monitor cpk if you go on high dose 80mg sim because it can make muscles and back pain, if so you can take paracetamol but for short period, in case of pain it is best to lower dose

[lagona]

I go with tenofovir + vitD3 20 000 ui in the morning and simvastatin 80mg at night before bed.
after taking simvastatin I just feel tired and sleepy immediately and wake up with normal mood with no pain at all.
Should I continue with the high dose or more test need to be done to assure the safety ?
Thank Stef2011 for always sharing a good info

[stef2011]

No no test strickly needed, you should feel a lot of pain before test cpk becoming elevated.tollerability is different person to person i remember i could tollerate 20mg not more

[stef2011]

very interesting articles that might give ideas on antiviral effect of simvastatin if there is any in vivo:

Cyclophilin A: a key player for human disease
in particular the paragraph: CyPA and hepatitis virus
http://www.nature.com/cddis/journal/v4/n10/full/cddis2013410a.html

simvastatin is a cpa inhibitor
http://circres.ahajournals.org/content/98/6/811.full