Long time efficacy of TENOFOVIR

[soa923]

Tenofovir is very effective in the treatment of chronic hepatitis b   Hbeag negetive patient , but my concern is that I want to find out the efficacy and safety of tenofovir in chronic hbeag negetive patient since most patient need treatment for life time 1) say efficacy for 20 years without causing any other damage to vital organ like kidney and probably any hope of hbsag loss or good viral suppression and improve liver condition and fibrosis regression

[ecinaj_1130]

thank you. do u think it's advisable for him to take anti viral med or interferon again?

[soa923]

Guys please let us educate ourselves well , information is good for us in this forum , please I want specific answer not base on rumor , what are the damaging effect of taking peg interferon on the body system ? Does it has any long time effect on any vital organ in body ? Finally is it not good to take the injection

[Jatashankar]

I ve read stem cell treatment for HIV cure but not hbv also it has severe sides due to chemos attached with it

[soa923]

Hi all members am appealing to all not to abuse each other on this forum we are here to share treatment experience and learn from each other . Our concern should be how to defect HBV in our body ... Hi Jason can you please tell us clear the side effect you experience while on peg inter treatment ?  So that we can learn as for me I didn't feel any side effect that will affect or run my life and make it worst than HBV . I will suggest if peg inter will add to health issue I av already no need to take it . That. Is my opinion . Please anyone with any information about the negetive effect of peg inter on body that out weight it's benefit of reducing the impact of HBV on the liver should tell us now so that we can learn from it

[ecinaj_1130]

Do you have idea about stem cell capsule?? i heard that this stem cell capsule can cure and eradicate the virus meaning HBSAG can be clear..

My husband is hepa b positive but hbeag is non-reactive, HBV DNA is undetectable since he had interferon shots for 6 months. But recently he has test since he finished the interferon treatment and unfortunately -- elevated SGPT, but still hbeag non-reactive.

His doctor advised him to do interferon treatment again for 6 months or anti viral drug (oral) for 1 year..

I need opinion guys.. is it okay to take anti viral drug again??

[StephenCastlecrag]

You have asked some very good questions. I try to answer with what I understand.
Tenofovir is so far 100% no drug resistance because of its high potency and high genetic barrier to drug resistance. High potency means it can inhibit viral replication quickly and highly effectively. With very low or undetectable viral load means NO Replication = NO Resistance. Secondly, it requires more than one genetic mutation in the hbv genome to affect the potency of Tenofovir.

Does frequent start-stop increase Tenofovir drug resistance. It is a moot point, but so far we don't have enough studies and clinical experiences to say one way or the other. I think for patients who suffered a rebound after stopping, resuming Tenofovir seems to work just as effectively as before stopping.

Just my opinion.