it worked this way on nap but who knows monotherapy
So basically its good when someone has lost HBsAg but has problems with developing antibodies ?
it doesn t work but when hbsag is unde or less than 1iu/ml works
it would be good to know if it can help also for hbsag less than 1000iu/ml when on tdf since 6 years, although very expensive i d use it if there was any data it can help in these cases but all trials i have seen it did n t work
Good to know that thymosin alpha has no sides. I'm on interferon now and I don't worry about temp sides but rather long term ones in case I'd have to repeat it in a few years.
Btw, so why thymosin alpha is not used as monotherapy or with nucs ?
6 month of follow up is barely enough to confirm a stable svr.
I do not b think that any agency will give approval based on 12 patients. They will, for hdv, negotiate a registration trial design with replicor.
BTW the current trial in Moldavia was NOT DESIGNED to achieve a functional cure. It's pupose was to show that the nap component was independently causing a strong, objective positive effect, BEFORE the interferon overlap.
The new trial, starting now is designed to achieve a functional cure in the hope that a full year of naps plus a simultaneous interferon or thymosin alpha treatment, all combined with TDF and with a TDF pretreatment period of 6 month, will achieve hbsag seroconversion in a high percentage of patients.
Those will be e neg patients again, but without hdv.
What is most fascinating is the thymosin alpha arm, since this has almost no side effects compared with interferon and seemed more promising in the second Bangladesh trial than interferon.
So it's 15 weeks on peginf left and than 6 months of observation ?