Persistent viral counts after Viread treatment

[ewachen97]

I am a chronic HepB carrier and recently start the treatment with Viread. After 3 month, there is no difference in my viral count. Has anyone experienced similar scenarios?

[stef2011]

in case you are in immune tollerance phase you need tdf+etv or tdf+ftc (truvada) to make hbvdna low and once undetectable you need peginterferon add on to have an immune response so that antivrals can be stopped or hbsag cleared
we have a member, i think nick is something like asianmale, he was treated while on tolerance phase and made tdf+etv combo to make hbvdna und and then added pegintf and cleared hbsag.

[stef2011]

post hbvdna tests baseline and at 3 months and confirm if they were made by the same lab

you may consider adding vit d3 10.000iu daily and entecavir to fasten response

[StephenCastlecrag]

It does seem unusual, however not knowing all the details, it is difficult to offer an explanation. Some factors that may affect response (not in any particular order):
1. immune status - in the Immune Tolerance or Clearance phase;
2. Initial viral load;
3. any previous exposure to Adefovir, drug resistance etc;
4. Compliance;
5. Viral loads measured at the same lab;
6. source of the drug.