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Positive - Negative - Negative (What does my test result mean?)

Regular blood donor with no notifications.  Most recent donation was July.

Hep B Core AB Total - Positive
Hep C Antibody IA - Negative
HBsAG - Negative
Hep B Surface AB, Qual - Negative

The following was noted under the Hep B Surface AB:

A negative Hepatitis B Surface Antibody is indicative of:
1) no prior exposure to HBV,
2) lack of antibody response to an acute or chronic HBV infection,
3) lack of antibody response to HBV vaccination, or,
4) loss of immunity that followed either vaccination or infection.

Would someone please tell me what this result means?  The Red Cross has never told me I have an issue.  My AST/ALT levels are in the teens.

My doctor hasn't returned any of my phone calls or contact attempts regarding the test result.  The office told me they would contact me with any issues if they popped up on my bloodwork.  Since the office and doctor have not contacted me, I'm not sure what I'm looking at when I read the results.

Any insight would be greatly appreciative.  Thanks!
Best Answer
Avatar universal
Hepatitis B is one type of viral hepatitis. Hepatitis means inflammation of the liver. It can be caused by the Hepatitis A, B, C, D, or E viruses. So I would not rely on further advice from the nurse.

The whole issue arises from the fact that you tested positive for HBcAb (everything else is negative). By testing positive to the Hepatitis B Core antibody, it means you have a current or past (but resolved)  Hepatitis B infection. But because you tested negative to the HBsAg, we rule out that you have a current infection. So we think you had a past but resolved infection. But as the doctor said, if you had a previous, but resolved Hepatitis B infection, you should have developed immunity, i.e., you should test positive to HBsAb, but your test is negative. But as Rome70 pointed out, if your previous resolved infection was old, you may have lost the HBsAb from your blood (even though the immune memory is there) and that is why he suggested that you may consider getting vaccination to regain that immunity. See point 4 of the explanation from the blood bank.

Finally, I am intrigued by why the specialist is interested in your travel to China, Japan and Israel. China is endemic for Hepatitis B. But Hepatitis B is not transmitted by casual contact, it is by blood to blood contact, by sex and vertically from your mother. So it is not where you have been, but whether you have the risk factors for infection.

To ease your mind, I am sure the specialist will order a repeated test and if he/she is a specialist, he/she will give you the right answer.

BTW, what country do you live in?
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Avatar universal
me and my husband are both healthy living, though my husband drink occasionally, we don't have any symptoms, but thanks for reply, soon we will go to hospital to have diagnos and to know the quantity if we really have that virus. thank you.
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Avatar universal
Equipment is operated by technicians who can make mistake. Almost all tests for Hepatitis B are for screening purpose, i.e., to test a person for the presence of a disease, as most people do not have symptoms. If you have symptoms and your doctor wants to confirm a diagnosis, then you have diagnostic tests. So the medtech is talking nonsense when he said it is only screening.
All tests, whether they are screening or diagnostic, should be accurate.

I am not a lab technician, but I would think, if a test is positive, the lab should test again to confirm the positive result.

Labs can make mistakes, so you will just have to accept results from a reputable lab such as those in a hospital or Red Cross, or have the results confirmed by another lab as your doctor has done.

Just my opinion.
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Avatar universal
hi, my  husband applying abroad in his medical he is hepa b reactive, then we consult another doctor but the test is Non-reactive, My husband brought the result to the clinic where he is Hepa B reactive, the medtech said it was only screening, the equipment they used is high tech, was it possible that the screening is non-reactive but in their equipment is Reactive?, i don't know the equipment called, i'm so confused. please help understand.
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Avatar universal
Congratulations! You don't have Hepatitis B.
Helpful - 0
Avatar universal
Last test in today:

HBV DNA Ultra

Negative for HBVDNA by PCR
Helpful - 0
Avatar universal
Another test result posted this morning:

Alpha 1 Antitrypsin Quant     129

*The Reference Range listed was 83 to 199 and the Unit: mg/dL

Alpha 1 Antitry Phen              PI*MM

*There was a note, "90% of normal individuals have the MM phenotype, with normal quantitative AAT levels."

I have no clue what any of this means.  Any ideas?  I looked for the HBVdna notes in all of the tests but didn't see anything so it appears I haven't had that test yet or its still pending out in lab work la-la-land.

Thanks!
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