http://isar.phrm.cf.ac.uk/system/files/23_icar_main.pdf
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Preliminary Evidence of Rapid HBsAg Seroconversion in
Patients with Chronic Hepatitis B (CHB) Treated with a DNAbased
Amphipathic Polymer
Mamun Al-Mahtab1,∗, Michel Bazinet2, Andrew Vaillant 2
1 Sheikh Mujib Medical University, Dhaka, Bangladesh; 2 REPLICor Inc.,
Montreal, Canada
Background: REP 9AC is a DNA-based amphipathic polymer
that targets viral glycoproteins important for viral entry and/or
release. REP 9AC has been previously shown to result in the rapid
clearance of surface antigen and the development of protective
immunity in DHBV infected ducks which results in 56% of treated
ducks achieving SVR (DHBV DNA negative) at 16 weeks posttreatment.
The ability of REP 9AC to treat human patients with CHB
is currently being evaluated in a proof of concept trial.
Methods: Patients with CHB were subjected to REP 9AC therapy
administered by slow continuous infusion. Safety and virologic
response (HBV DNA, HBsAg, anti-HBs) were assessed weekly, either
at the trial site or by confirmatory testing (HBsAg, HBeAg, anti-HBs,
anti-HBe) of frozen serum samples at a separate location using the
ArchitectTM testing platform.
Results: All patients treated to date have cleared HBsAg and
developed protective immunity (anti-HBs) which was observed as
early as 7 days following initiation of treatment at higher doses. At
the time of abstract submission, one patient has already exhibited
clear signs of a sustained virologic response (HBV DNA−, HBsAg−,
HBeAg−, anti-HBs+, anti-HBe+) for 12 continuous weeks off treatment
after receiving only 23 weeks of treatment with REP 9AC.
Conclusions: These results demonstrate that amphipathic polymers
are effective in rapidly reducing HBsAg levels in CHB patients
which is a critical event for allowing patients to achieve a rapid
seroconversion. Subsequent rapid appearance of anti-HBs and anti-
HBe antibodies observed in these patients are the best indicators
for achieving SVR and suggest that amphipathic polymers could
become an important new tool in the treatment of CHB.
This information is giving me a great hope. Thank you so much for sharing, you people are so great.
When we can expect this drug released to market.
REP 9AC is now available ?
--Not yet.
what is REP 9AC??
--A drug under testing.
REP 9AC is now available ?