Aa
Starting IFN next month.
Hi all,
I will be starting a mono IFN therapy in 5 weeks time. After deliberating about it for the last 6 months, I think I need to at least give it a try. I just missed the trial for IFN/TDF in FEB this year because my viral load was too low for this trial (one of the criteria).
Lastest blood test today confirm HBV DNA has increased from 200iu/ml (2 logs) to 20000iu/ml (4 logs) in 3 months. These are approx. numbers and I didn't ask for a print on the result. We don't measure HBsAg in this hospital, which is not good. HBV DNA fluctuating between these number for the last 12 months.
Latest ALT steady at 40, AST at 34, GGT 16, ALP 52 and Bilirubin at 7.
My history:
Last ETV pill was on Dec 2011. During this treatment (somewhere in between stopping), I convert from HbeAg-Positive to HBeAg-Negative, e-antibody negative to e-antibody positive. Doctor ask me to stop after approx. 18 months. It was not my choice. I think it's because my HBV DNA was UND for a few months and my ALT value was below 40.
I will be starting a mono IFN therapy in 5 weeks time. After deliberating about it for the last 6 months, I think I need to at least give it a try. I just missed the trial for IFN/TDF in FEB this year because my viral load was too low for this trial (one of the criteria).
Lastest blood test today confirm HBV DNA has increased from 200iu/ml (2 logs) to 20000iu/ml (4 logs) in 3 months. These are approx. numbers and I didn't ask for a print on the result. We don't measure HBsAg in this hospital, which is not good. HBV DNA fluctuating between these number for the last 12 months.
Latest ALT steady at 40, AST at 34, GGT 16, ALP 52 and Bilirubin at 7.
My history:
Last ETV pill was on Dec 2011. During this treatment (somewhere in between stopping), I convert from HbeAg-Positive to HBeAg-Negative, e-antibody negative to e-antibody positive. Doctor ask me to stop after approx. 18 months. It was not my choice. I think it's because my HBV DNA was UND for a few months and my ALT value was below 40.
In his case it can reactivate, hbsab around 1000 is absolutely protective, he just needs ultrasound monitoring for liver cancer
if available i would just check nagalase, another member who reached hbsag almost und and no antibodies, had nagalase still abnormal.maybe this test reflects the cccdna and the liver cancer risk not zero on those with hbsag loss
if available i would just check nagalase, another member who reached hbsag almost und and no antibodies, had nagalase still abnormal.maybe this test reflects the cccdna and the liver cancer risk not zero on those with hbsag loss
Congratulations :) great HBsAb count, like after vaccacine :)
But I think you should monitor it anyway, I know you want to forget about the disease but even people who lost HBsAg should be under monitoring especially older ones. It happends veeeery rarely that it reactivates.
So your fibrosis reversed just by diet, from F2 to 4.9 which is F0 or low F1 I suppose ?
But I think you should monitor it anyway, I know you want to forget about the disease but even people who lost HBsAg should be under monitoring especially older ones. It happends veeeery rarely that it reactivates.
So your fibrosis reversed just by diet, from F2 to 4.9 which is F0 or low F1 I suppose ?
Drinking alcohol is fine in moderation Safisifa. You got to live a little.
Just got back from my 6 monthly check up. Dr said I don't need to come in anymore. HBsAg and HBV DNA undetectable. No measurement for HBsAB but 6 months ago, it was 953. For some reason, no LFT result as I think it was not on the blood form. Last IFN injection was 25th June 2014.
Did a fibroscan that day as well. It only took like 2 minutes. Result was given on the spot as 4.9.
I will check the website from time to time to help fellow patient seeking help and advice. A big thank you to Stef2011 and StephenCastlecrag for all the education given regarding this disease and wish everyone all the best in the future.
Just got back from my 6 monthly check up. Dr said I don't need to come in anymore. HBsAg and HBV DNA undetectable. No measurement for HBsAB but 6 months ago, it was 953. For some reason, no LFT result as I think it was not on the blood form. Last IFN injection was 25th June 2014.
Did a fibroscan that day as well. It only took like 2 minutes. Result was given on the spot as 4.9.
I will check the website from time to time to help fellow patient seeking help and advice. A big thank you to Stef2011 and StephenCastlecrag for all the education given regarding this disease and wish everyone all the best in the future.
Could you please delete the comment that you said you drink alcohol? Because there are many people that can misunderstand your saying and start drinking alcohol.
Sometimes during the treatment, I had quite a few drinks on the weekend. I don't drink wine. I quit smoking in year 2011 or so. Changed diet in 2013.
My nurse say it's fine as we must indulge in our lives. Once my GGT went up to the high 80's and I suspect alcohol to be the cause plus also IFN does cause GGT to spike.
I am not an avid drinker, just every now and then. Wine once a week should be fine. :)
My nurse say it's fine as we must indulge in our lives. Once my GGT went up to the high 80's and I suspect alcohol to be the cause plus also IFN does cause GGT to spike.
I am not an avid drinker, just every now and then. Wine once a week should be fine. :)
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