Aa
Starting IFN next month.
Hi all,
I will be starting a mono IFN therapy in 5 weeks time. After deliberating about it for the last 6 months, I think I need to at least give it a try. I just missed the trial for IFN/TDF in FEB this year because my viral load was too low for this trial (one of the criteria).
Lastest blood test today confirm HBV DNA has increased from 200iu/ml (2 logs) to 20000iu/ml (4 logs) in 3 months. These are approx. numbers and I didn't ask for a print on the result. We don't measure HBsAg in this hospital, which is not good. HBV DNA fluctuating between these number for the last 12 months.
Latest ALT steady at 40, AST at 34, GGT 16, ALP 52 and Bilirubin at 7.
My history:
Last ETV pill was on Dec 2011. During this treatment (somewhere in between stopping), I convert from HbeAg-Positive to HBeAg-Negative, e-antibody negative to e-antibody positive. Doctor ask me to stop after approx. 18 months. It was not my choice. I think it's because my HBV DNA was UND for a few months and my ALT value was below 40.
I will be starting a mono IFN therapy in 5 weeks time. After deliberating about it for the last 6 months, I think I need to at least give it a try. I just missed the trial for IFN/TDF in FEB this year because my viral load was too low for this trial (one of the criteria).
Lastest blood test today confirm HBV DNA has increased from 200iu/ml (2 logs) to 20000iu/ml (4 logs) in 3 months. These are approx. numbers and I didn't ask for a print on the result. We don't measure HBsAg in this hospital, which is not good. HBV DNA fluctuating between these number for the last 12 months.
Latest ALT steady at 40, AST at 34, GGT 16, ALP 52 and Bilirubin at 7.
My history:
Last ETV pill was on Dec 2011. During this treatment (somewhere in between stopping), I convert from HbeAg-Positive to HBeAg-Negative, e-antibody negative to e-antibody positive. Doctor ask me to stop after approx. 18 months. It was not my choice. I think it's because my HBV DNA was UND for a few months and my ALT value was below 40.
you can try bluberries extract for that and probiotics, then if they dont work go for the antibiotic
also consider colloidal silver in correct doses, a study just presnted about silver conifrmed it can increase antibiotic response 1000folds even on resistance bacteria.silver is also toxic so the correct dose must be used
also consider colloidal silver in correct doses, a study just presnted about silver conifrmed it can increase antibiotic response 1000folds even on resistance bacteria.silver is also toxic so the correct dose must be used
Hi all,
After 2 shots of IFN, my blood test shows I am very low in WBC and neutrophils. My ALT has increased from 52 to 130. No measurement on viral load until the 4th week and as always, the Doc say HBsAg is not needed or available.
The Doc has suggested me decreasing the dose to 90mcg tonight and do another blood test next week before the 4th shot.
Any comment? Do any of you have such a decrease in WBC and neutrophils in the first few weeks?
After 2 shots of IFN, my blood test shows I am very low in WBC and neutrophils. My ALT has increased from 52 to 130. No measurement on viral load until the 4th week and as always, the Doc say HBsAg is not needed or available.
The Doc has suggested me decreasing the dose to 90mcg tonight and do another blood test next week before the 4th shot.
Any comment? Do any of you have such a decrease in WBC and neutrophils in the first few weeks?
yes I did... first shots have stronger impact on WBC then they will stabilize.. I had to reduce dose to 135mcg... what about platelets count?
Any comment? Do any of you have such a decrease in WBC and neutrophils in the first few weeks?
fist of all the lowering dose is 130 and not 90, pegintf doesn t work already at 130, 90 may be totally useless
what are the numbers?they must be extremely low to change dose and before changing doses it is best to go for supplements and if they dont work go for drugs
without hbsag quant you will not know if you are responding and if it is best to stop at 24 weeks for non response....have you planned to sip blood sample to europe or india for hbsag testing?
fist of all the lowering dose is 130 and not 90, pegintf doesn t work already at 130, 90 may be totally useless
what are the numbers?they must be extremely low to change dose and before changing doses it is best to go for supplements and if they dont work go for drugs
without hbsag quant you will not know if you are responding and if it is best to stop at 24 weeks for non response....have you planned to sip blood sample to europe or india for hbsag testing?
Not yet Stef. Because it will be costly and time consuming, I did not want to send blood sample overseas. Also, these sample will need to be done quite a few times over the course of treatment.
To grmr, I wasn't given any figures, just by word of mouth. I heard that neutrophils has decrease to a third of something. Also that it's quite common for this to happen so as I don't panic.
To Stef, I think the WBC and neutrophils were quite low. My ALT has increased quite a lot. Before that, it was between 40 and 67 for about 2 years.
All in all, I am just going to pray and hope everything is business as usual.
To grmr, I wasn't given any figures, just by word of mouth. I heard that neutrophils has decrease to a third of something. Also that it's quite common for this to happen so as I don't panic.
To Stef, I think the WBC and neutrophils were quite low. My ALT has increased quite a lot. Before that, it was between 40 and 67 for about 2 years.
All in all, I am just going to pray and hope everything is business as usual.
Not yet Stef. Because it will be costly and time consuming, I did not want to send blood sample overseas. Also, these sample will need to be done quite a few times over the course of treatment.
hbsag quant is extremely cheap, it is 7euros here and i guess india is even cheaper, as to courier tnt is about 60-70€ from here to asia, you can use slow/economy because hbsag is very stable.it should not be expensive
I think the WBC and neutrophils were quite low.
WBC can get very low and no worries, even 3 or 2.5 is ok.neutrophiles are more important and as long as they are >0.5 you don t need to worry.platlets are also the most important you can keep full dose as long as they are not less than 25.000
of course expert doctor on pegintf therapy are needed because these numbers are quite lower than normal range but liver specialist very experienced on pegintf therapy know what is the range and the drugs to use in case neutrophils or plts get too low, the ignorant messed up....doctors/butchers make mess as soon as they see lowering numbers which is normal on pegintf or having an immune response...the lowering of plts, wbc and neutrophils mean these cells are gathering in the liver where the battle is
i do hope they will manage everything ok so that you ll clear, are you combo with etv?
hbsag quant is extremely cheap, it is 7euros here and i guess india is even cheaper, as to courier tnt is about 60-70€ from here to asia, you can use slow/economy because hbsag is very stable.it should not be expensive
I think the WBC and neutrophils were quite low.
WBC can get very low and no worries, even 3 or 2.5 is ok.neutrophiles are more important and as long as they are >0.5 you don t need to worry.platlets are also the most important you can keep full dose as long as they are not less than 25.000
of course expert doctor on pegintf therapy are needed because these numbers are quite lower than normal range but liver specialist very experienced on pegintf therapy know what is the range and the drugs to use in case neutrophils or plts get too low, the ignorant messed up....doctors/butchers make mess as soon as they see lowering numbers which is normal on pegintf or having an immune response...the lowering of plts, wbc and neutrophils mean these cells are gathering in the liver where the battle is
i do hope they will manage everything ok so that you ll clear, are you combo with etv?
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