Aa
What now?
Hi Everyone,
First off I would like to thank everybody here for contributing to the forum. You guys have provided an enormous amount of information and support for everybody. Ever since I found out I had chronic hepatitis B, I was in shock. My life totally changed for the worst. I use to have a wonderful social life and everything, but now it's the total opposite. I'm hoping in the future my social life can slowly return to some degree of resemblance. I know I have to take care of my liver from now on and try to stay away from alcohol. Ever since the doctor told me to avoid alcohol, I touched it very little - a little sprinkle of whisky with a glass of soda, or mixing 1/3 glass of beer with water.
I just got the results from my last blood test. The doctor congratulated me and told me that HBV DNA was undetectable and that my liver was no longer inflamed, AST was 28, and ALT was 38.
Just back on 30 June 2010 my blood test showed the following:
Hbsag pos
Anti hbs neg
Anti hbc igm neg
Hbeag pos
HBV DNA > 110,000,000 IU/ml
Liver biopsy: marked piecemeal necrosis, mild intralobular degeneration, moderate portal inflammation, fiberous portal expansion. Knodell score: 9.
Diffuse alteration of the periportal plate in all portal tracts, absent of bridging and confluent necrosis, at least one necroinflammitory focus per lobule, mononuclear aggregates in all portal tracts and stellate enlargement of portal tracts without septae formation. Metavir score: 7
Here are test results for 2005 and the past few months:
29 Sept 2005
AST 20
ALT 23
3 Aug 2010
AST 115
ALT 308
Does this mean that I contracted Hep B sometime between 2005 and 2010?
17 Aug
AST 112
ALT 230
14 Sept
AST 202
ALT 355
I think my enzyme levels increased during this period because I smoked pot for 3 nights straight thinking that it wouldn't affect my liver. Was I wrong!
26 Oct
AST 28
ALT 38
HBV DNV undectable
How meaningful are the above results? Or is it too early to tell?
I began my first injection of Pegasys back on 3 August and have already taken 13 injections. My question is what now? The doctor tells me that I have to take Pegasys until the very last injection (injection 48). Is this true or does he just want my money?
Is there any chance that I may have immunity now? Or is it too early to tell and I just need to continue taking the Pegasys injections?
What are the chances that I will seroconvert and test HbSag (Negative) and HbEag (Negative) in the future? When should I go get tested again?
Does this mean that my liver can begin repairing itself now? Will my liver be able to return to its original state before I contracted the virus?
In my current state, do I still need to stay away from alcohol? Can I drink once in a while? Should I wait until my very last injection before taking a drink?
Thanks everyone.
First off I would like to thank everybody here for contributing to the forum. You guys have provided an enormous amount of information and support for everybody. Ever since I found out I had chronic hepatitis B, I was in shock. My life totally changed for the worst. I use to have a wonderful social life and everything, but now it's the total opposite. I'm hoping in the future my social life can slowly return to some degree of resemblance. I know I have to take care of my liver from now on and try to stay away from alcohol. Ever since the doctor told me to avoid alcohol, I touched it very little - a little sprinkle of whisky with a glass of soda, or mixing 1/3 glass of beer with water.
I just got the results from my last blood test. The doctor congratulated me and told me that HBV DNA was undetectable and that my liver was no longer inflamed, AST was 28, and ALT was 38.
Just back on 30 June 2010 my blood test showed the following:
Hbsag pos
Anti hbs neg
Anti hbc igm neg
Hbeag pos
HBV DNA > 110,000,000 IU/ml
Liver biopsy: marked piecemeal necrosis, mild intralobular degeneration, moderate portal inflammation, fiberous portal expansion. Knodell score: 9.
Diffuse alteration of the periportal plate in all portal tracts, absent of bridging and confluent necrosis, at least one necroinflammitory focus per lobule, mononuclear aggregates in all portal tracts and stellate enlargement of portal tracts without septae formation. Metavir score: 7
Here are test results for 2005 and the past few months:
29 Sept 2005
AST 20
ALT 23
3 Aug 2010
AST 115
ALT 308
Does this mean that I contracted Hep B sometime between 2005 and 2010?
17 Aug
AST 112
ALT 230
14 Sept
AST 202
ALT 355
I think my enzyme levels increased during this period because I smoked pot for 3 nights straight thinking that it wouldn't affect my liver. Was I wrong!
26 Oct
AST 28
ALT 38
HBV DNV undectable
How meaningful are the above results? Or is it too early to tell?
I began my first injection of Pegasys back on 3 August and have already taken 13 injections. My question is what now? The doctor tells me that I have to take Pegasys until the very last injection (injection 48). Is this true or does he just want my money?
Is there any chance that I may have immunity now? Or is it too early to tell and I just need to continue taking the Pegasys injections?
What are the chances that I will seroconvert and test HbSag (Negative) and HbEag (Negative) in the future? When should I go get tested again?
Does this mean that my liver can begin repairing itself now? Will my liver be able to return to its original state before I contracted the virus?
In my current state, do I still need to stay away from alcohol? Can I drink once in a while? Should I wait until my very last injection before taking a drink?
Thanks everyone.
Hearing you say that I've "almost seroconverted" really gives new found outlook in life. I will continue to take Pegasys until week 48 and hopefully I will be positive for Anti-hbs by week 48. Have you ever heard anyone with chronic hepatitis B gaining immunity? Is it possible?
Just to let you know, ever since I started my Pegasys injections, I've also been taking vitamin b complex, centrum multi vitamin, vitamin e and folic. I haven't missed a single dose of my vitamins yet. Maybe it will work for others.
Just to let you know, ever since I started my Pegasys injections, I've also been taking vitamin b complex, centrum multi vitamin, vitamin e and folic. I haven't missed a single dose of my vitamins yet. Maybe it will work for others.
My doctor said to me the same, whan you are HbsAg -, and anti-HbsAg- its 75% for seroconversion. i got seroconversen 4 weeks after theraphy ( i was 48weeks on theraphy).
i know how u feel.
tell me when will u finish your theraphy?
u must wait little time :)
when i was on theraphy i didnt drink alcohol but two times in mounts i have smoked canabis, but dont do that. its not recomended.
i know how u feel.
tell me when will u finish your theraphy?
u must wait little time :)
when i was on theraphy i didnt drink alcohol but two times in mounts i have smoked canabis, but dont do that. its not recomended.
this january 2011 is a very good month you are the 3rd or 4th person close to hbsag seroconversion that posted
HBsAg - Non-reactive (titer 0.73 s/n)
Anti-HBs - Non-reactive (titer 0.8 mlU/ml)
i was thinking about this test and you have almost seroconverted, very very close to it.
hbsag test with s/n has sensibility at 1-2s/n which is not zero yet bt very close, so congratulations and let us know when hbsab gets higher than 10miu/ml
also do not stop interferon until hbsab gets high much higher than 10
Anti-HBs - Non-reactive (titer 0.8 mlU/ml)
i was thinking about this test and you have almost seroconverted, very very close to it.
hbsag test with s/n has sensibility at 1-2s/n which is not zero yet bt very close, so congratulations and let us know when hbsab gets higher than 10miu/ml
also do not stop interferon until hbsab gets high much higher than 10
Thank you so much for your thoughts
stopping Pegasys because they said they were "cured.
i guess ignorant doctors considering hbvdna und and hbeag seroconvertion as a cure, which of course that is not, the most will relapse by a couple of years if hbsag positive and not decreasing
interferon mono has only 11% making hbsag negative by 5 years, response to 48weeks is much much lower.i have also seen higher percentages than 11% at 5-10years but again this happens in those with very low hbsag at the end of 48weeks and with a slow decreasing pattern
my idea is the hbv is considered a business like hiv since the virus integrates inthe cells and complite eradication is difficult, and i do consider very starnge that we are still at mono therapies when we do know there is no hbv eradication with mono.
on the contrary hiv and hcv have gone straight to the combos
i guess ignorant doctors considering hbvdna und and hbeag seroconvertion as a cure, which of course that is not, the most will relapse by a couple of years if hbsag positive and not decreasing
interferon mono has only 11% making hbsag negative by 5 years, response to 48weeks is much much lower.i have also seen higher percentages than 11% at 5-10years but again this happens in those with very low hbsag at the end of 48weeks and with a slow decreasing pattern
my idea is the hbv is considered a business like hiv since the virus integrates inthe cells and complite eradication is difficult, and i do consider very starnge that we are still at mono therapies when we do know there is no hbv eradication with mono.
on the contrary hiv and hcv have gone straight to the combos
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