Will KEYTRUDA (pembrolizumab)‎ be enough to fight HCC?

[itac]

Keytruda mechanics is based on preventing the T-Cell Blocker cell from having the T- Killer Cell (immune system) to fight the cancer cell... Since hbvers have their immune system supressed by the hbsag secretion, would it be enough to use Keytruda to fight liver cancer (HCC) if needed? Or since the immune system is supressed by the hbsag, you will need to combine Keytruda with a drug like ARC-520 to silent the hbsag gene expression, and that way you could have the immune system fight the cancer cells? I guess it's a little but more complex since there is also viral infected cells.

Would be interesting to hear stef/studyforhope opinions about this.

Btw, are there any active clinical trials about Keytruda effectiveness against HCC with or without ARC-520?

Thanks!

[itac]

yes that's the drug I was referring to... Although it only has 25% success rate on the current cancer types it treats... I know they are running many trials for it against different kinds of cancer... Would be interesting to see what would be the result for liver cancer...

[twinboys1girl4me]

I believe this was the drug that was just in he news from former President Carter?  From Keytruda's website it has a lot of contradictions for hepatitis or liver issues.  Have you read of trials being used on HCC?  I read of this being used because a patient had metastasis to the liver, but haven't read anything about primary HCC.  They are very different.  My aunt had ovarian cancer that spread to her lungs, stomach, liver, and more and by treating the primary source it took care of the cancer that had spread to other places.  This was 4 years ago and she is still cancer free.  https://www.keytruda.com/