hbsag quantity

[stef2011]

today i received my hbsag quantity which is 250iu/ml, if i only knew about this before starting therapy we would have choosen interferon since etv has little/no impact on this.

interferon leads to hbsag seroconversion when hbsag is less than 1600iu/ml which is the level of inactive carriers, etv has almost no impact on hbsag and cccdna eratication so it was a wrong choice.

i will keep monitoring and taking sun to increase vitamin D level which might have helped on hbsag level and wait to receive and start alinia which has a proven impact in lowering hbsag

i do suggest to check hbsag and although it is rare on cronic hbv to have it lower than 1600iu/ml (on cronic is usually 3000-10000) but it is better to check it so correct therapy can be choosen from the begining

[raja1972]

I happened to read the discussion on Milk thistle and started digging it in the net and found some promising info.  It helps curing the damange of liver cells as well as helping the growth of new cells.  Milk thistle is part of siddha (indian) medicine and i have asked a siddha doctor about the dosage, side effects among other things.  Will keep you all posted about it.  If it is going to help the liver and no side effects why not using it in recommended dosage?

[raja1972]

Again, thanks for your clarification.  Have another question.

My Mom died of cirrhosis due to HCV.  is there any chance for me got infected from my mom (that's what My wife and I believe).  is it possible to get HBV from HCV infected person?

[stef2011]

there are many things that increase the chance of getting HCC but in any case it is a very low percentage of risk so it doesn t make much sense to make hbvdna undetactable if there is no liver damage, no family history of HCC, no mutants like precore and others to promote hcc risk, genotypes differenty than C

the bad side is that most healthcare systems and insurances focus and allow only tests to use antivirals and make money from you instead of checking the real tests to see your health, especially in US there is only hbvdna which is just a test to push towards antivirals and so getting money from patients and not making what is really healthy for them

so you need more than just hbvdna:
genotype
precore-bcp muattions
hbsag quantity in iu/ml (a lowering of more than 70% hbsag reduces HCC in vitro)
liver damage by biopsy or fibroscan

or if you just want to cut all of these take tenofovir but this is not the best choice because this antiviral has sides effects on the long period
hbvdna undetactable prevents HCC but not totally HCC develops even if hbvdna und although the percentage of patients is much lower

[raja1972]

Hi stefano,
My HBVDNA level is 66K iu/ml (4.6 log).  what would be chance for getting HCC?
Right now i am on medication (siddha - indian medicine) for a month.  I will be taking the DNA test after seeing the doctor next week.

Thanks a lot for your data points.  It is really helping to understand things better.

[stef2011]

looks like i have to wait until my alt / ast get increase, in order to achieve the best result for interferon?

yes increase of alt/ast or increase of hbcab igm quantity, this means immune system is getting activated while now it is stable/dormant

taking alinia first increases response to interferon (alinia 4weeks before interferon), i d definitely try alinia and see if it makes any difference

[iwanttobeheal2]

my hbv dna is already come,

the hbv dna result is exactly steady, it not increase, means not getting worse

both my ast alt is normal, even getting lower. ( 15 and 19 )

only my hbsag quanti get increase.

any comment stefano? looks like i have to wait until my alt / ast get increase, in order to achieve the best result for interferon?

since i believe no liver damage at all by now.

thank you