tag reports on new drugs development 2010

[stef2011]

http://www.treatmentactiongroup.org/uploadedFiles/About/Publications/TAG_Publications/2010/2010%20pipeline%20webFINAL.pdf

interesting articles about new drugs but looks like there is almost no intrest from drug makers to develop the drugs, only a failed hiv drug has been renewed for hbv

Hepatitis B Clinical Research Network is blocked by drug makers being at the 3rd years without any single patient enrolled in the studies, disgusting....(funds will be available for other 4 years and then the network will probably close)

the only interesting news:
The University of Oklahoma and the U.S. Veteran’s Administration are conducting a
phase I proof-of-concept study looking at the cholesterol lowering agent simvastatin, after
in vitro data showed anti-HBV activity and synergistic activity when combined with
approved HBV drugs (Bader 2010).
The small three-arm study will compare simvastatin
alone vs. simvastatin with either tenofovir or entecavir. Since the drug is available as a
generic, it will radically change the current HBV market if proven effective on its own.

but this study has been planned from years (and i always go check for results) but looks like they don t find patients...., if it will not start by 2010 we can be sure sim works a lot and at this point we can do trials on our own.....

[Sharp7]

I agree... this is the way things seem to go these days. The price we all have to pay for relying on western companies with western laws.

India and China seem too damn muddleheaded to do good research. With millions of people infected, and entirely different laws, they could do so much there... but on the whole, I'm disappointed with the quality of research done there. Speaking for Indian universities, I saw enough to get the impression that rampant corruption is the reason why things are the way they are.

[stef2011]

my point of view is:
drug makers are trying to slow research and making no drugs because they have found the best point by etv and tnf (not to say the mess done with lam and adv), and doctors are pretty stupid to stay with what they do without making combos

etv and tnf do not clear virus but we have to keep buying it to keep hbvdna und, hopefully for them we will develop resistance in 10-15years so that we must switch to a new patented and extra expensive drug

i do hope ntz and sim will work more than etv and tnf so that the million market will change complitely to the cheap and normal market of generic drugs

[Sharp7]

I just don't understand why Hep C get so much more attention everywhere... including MedHelp. The PDF you linked to has 6 pages on B, compared to about 20 on C

I will be thankful for that only when I, or someone else I care about, get Hep C. Until then, it is just noise.