An update on Wk.12 Study Results

[willbb]

Well,I received my Trial Labs yesterday and unfortunately I am still DET. @ 284 IU/ml.
For those of you that don"t know,I am a Geno1a,with Stage1(fib).

I had a Base L (vl) of 9.7 Mill.

My trial is 80% chance of taking a P.I  and 20% Placebo(obviously no way to know at this point) The study is unblinded in 15 months.

I have been fortunate to have had basically no s.x .(so far) and my bloods are all in the normal R.R.

Not being UND. at  WK.12 I realize that my % of SVR have been lowered somewhat and chances of relapse have been increased somewhat.

So...my dilemma..Should I put  Tx. on hold for now,wait for the trial to be unblinded (see what I was taking ) watch and research resistance profiles,and revisit  Tx. when the new meds are avail. or do I plunge ahead and try to knock down the rest and take my chances?

My reaction is to not give up on this,especially since I have committed to a  study and it"s not my nature to quite something,however I keep looking at the stats  and it is a tough call on my part.

Any thoughts and advice folks would be greatly appreciated.

  Thx.

WILL

[willbb]

Dave  ..sorry that wasn"t clear....if you were on the study drug and did not go UND at  wk.4 then at wk.12 you were put on SOC.

[willbb]

Hi Dave...The way the trial worked was this ... if you were on the study drug and did NOT go UND atwk.4  you were taken off of it...that is my case  I am definitely just SOC now ..if I cont.

I agree with you entirely  that these drugs are  very toxic...and that will weigh in my decision next wk.

I did not have a breakthrough..I won"t say too much about how I know that... other than I just know for certain..

And  thanks for your best wishes Dave.. the same to you.

WILL

[spectda]

Hi Will-
I am really sorry that your result is not better. It's really difficult to not be disappointed. From what I understand there is a chance that the drugs can be changed in your trial at week 12. If that is correct that it is of course a game changer.

I hate to see anyone take these drugs any longer then they have to. I believe that regardless of the sx they are highly toxic and the less time we take them the better. The good news as you said is that you are stage 1 and you have backup in Boceprevir or Telaprevir in the near future if this doesn't work for you.

I don't believe you've had a breakthrough either, I am sure the trial has strict guidelines about stopping if there is a breakthrough because I believe the FDA is very concerned about dominant variants developing.

Your trial seems more flexible then my boce trial about what is considered a good response and time to stop. In my trial if not und at week 12, the doctor had the discretion to go on only another couple of weeks only if I was in very close range as in 25-50 iu/ml. The difference if I am understanding correctly is that your drugs might be changed so it seems even more difficult to make a decision.


I wish you the best Will. This is tough news but you have lots of options and will beat this beast before long.

good luck,
Dave

[willbb]

Babs and Uncledudeness:   Thx  for that!

WILL

[uncledudeness]

sorry to hear this will. we all had such high hopes for this trial, but it's not over yet. with 80/20 odds, i was big on the trial; i still am. but you roll with it. you will clear. stay positive and keep fighting.

[blondie717]

Went and visited site I was on while I was booootted from here. The fine folks there are seeing some Und. With bms790052. Good for them.. I dont think that sight likes pharma, tx, and clinicaltrials. But there real nice folks. I hope you guys kill it this time around. And Im going to my 12 wk... Satan my kitten tried to eat one of my Riba, bit me 2 X's , scratched my nose and made me bleed (alot) I washed her paw as Im taking no risk of giving a hep to my rotten little evil kitten! I should of dunked her in toilet tank!