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Bioavailability: Getting the best out of your food

This article easily explains concepts we use all of the time.  Given the level of sophistican of the HCV forum membership it is probably remedial.

One interesting tid-bit: The phenols in tea and coffee inhibit iron absorption.
One observation: The writer starts a lot of sentences with "But." (Received a red check mark for that once) :D

Here is the link:     http://news.bbc.co.uk/2/hi/health/4777607.stm

Here is a cut and paste:

A balanced diet is the key to a happier, healthier life, so the mantra goes.
Experts advise us to eat more fruit and veg; boost protein and fibre intake; make sure we get the optimum levels of vitamins and minerals.

But what actually happens to these nutrients once they are inside the body?
Food scientists, working in an area called bioavailability, are trying to answer this question in a bid to discover how people can get the very best out of what they eat.

Toni Steer, a nutritionist at the Medical Research Council Human Nutrition Research Centre in Cambridgeshire, said: "The idea that we absorb everything we eat just isn't true.
"While you may have a certain amount of a nutrient within a food, what is actually absorbed may be less.

"Bioavailabity means how much of that nutrient within a food is usefully absorbed."

But, she says, bioavailability is not set in stone, and researchers are working to find ways of manipulating the levels of nutrients that can be absorbed by the body.  "If people are meeting dietary requirements, all of the nutrients they need are probably being absorbed.  "But for people who suffer vitamin or mineral deficiencies, or for those in developing countries where nutrition is poor, research into bioavailability can be very useful."

Pop-Eye's favourite
Take iron - a lot of people are just not getting enough of it, and too little can lead to anaemia and increased susceptibility to infections.
But how we get our iron can impact on the amount we absorb, says Richard Faulks, a senior researcher at the Institute of Food Research in Norwich.

While red meat contains the type of iron - haem-iron - that is most readily absorbed by the body, vegetarians are pointed towards iron-rich foods such as spinach.  However, this vegetable contains the mineral in a form that is not so readily absorbed - non-haem iron.  Tinned tomatoes are a better source of antioxidants

But, explains Mr Faulks, a glass of orange juice alongside your plate of spinach can make all the difference.
"Vitamin C in orange juice changes the iron to its non-oxidised state (haem iron) - which is much more readily absorbed than the oxidised iron (non-haem iron).
"You can manipulate to some extent the gastric and small intestinal chemistry by what you eat and combine."

Conversely, explains Dr Steer, tea and coffee contain compounds called phenols that inhibit iron absorption - so they shouldn't be consumed alongside iron-rich foods.

Raw vs cooked:  Whether your food is raw or cooked can also make a difference.

Tomatoes contain lycopene, a form of antioxidant. Antioxidants have been hailed for their ability to neutralize free radicals, which are linked to ageing, stroke and heart disease.

"If you have fresh tomatoes, they have a total antioxidant potential of about 80," explains Dr Catherine Collins, a dietician at St George's Healthcare NHS Trust.   Once you can manipulate how nutrients are delivered into the body, it can help you to tailor a product that can deliver certain attributes Richard Faulks

"But if you boil or can them the antioxidant potential goes up five or six-fold."

"This happens because the lycopene in the raw tomato has been transformed to trans-lycopene in the cooked version, and trans-lycopene is much more readily absorbed."

Likewise, says Dr Collins, cooking carrots makes the beta-carotene, another form of antioxidant, more available because you break down the cell wall with the cooking process.


A nutrient's relationship with water and oil can also alter bioavailability.

Mr Faulks said: "To absorb fat-soluble nutrients, you have to get them out of the cellular structure, and then they have to be transferred into lipophilic - or fat-loving - carriers in the gut to be absorbed."

Lutein is one such nutrient. Present in spinach and other green vegetables such as kale, broccoli and peas, some evidence suggests it can protect or slow age-related macular degeneration, a leading cause of blindness.

Dressing some raw vegetables with oil helps nutrient absorption

"Lutein is actually absorbed more efficiently if it is eaten with a little bit of fat, the oil helps it to hop onto to the fatty acids in the gut and to be absorbed," said Dr Steer.

Mr Faulks believes bioavailability is a growing area, and something that has the potential to impact on the health-food industry: "Once you begin to understand and can manipulate how nutrients are delivered into the body, it can help you to tailor a product that can deliver certain attributes."

However, says Dr Steer, it is a complex field, especially because different nutrients interact in different ways.

"For a long time breakfast cereals have been fortified with added iron. But they also contain phytates - a form of energy store - which are present in whole-grain cereals, and these actually inhibit the absorption of iron.

"And calcium in dairy products can also inhibit iron absorption. So you have your cereal with iron and phytates, but then you pour on your milk that will also contribute to inhibition of the absorption of iron. It can get very complicated."

Jigsaw puzzle

According to researchers, there are pros and cons of combining food in this way.

By cooking tomatoes to gain antioxidants, vitamin C is degraded. By adding fats to green vegetables, your cholesterol intake is boosted.

And, experts add, more is not always best. High intake of some vitamins and minerals has been associated with risks.

But, says Dr Steer, the more we understand about how the body absorbs nutrients, the better the dietary recommendations we can make.

"It is all about understanding how these nutrients are absorbed in the body, and how much of them we need to reduce or even prevent certain diseases while avoiding any adverse symptoms.

"Understanding bioavailability it is really part of the jigsaw of understanding optimum nutrition."

5 Responses
Avatar universal
You are not what you eat,but what you absorb tru the small intestine...if your intestine is impacted with fecal matter...you wont even be able to absorb the RIBA  as well....or anything else...COMMON SENSE AGAIN
314554 tn?1337457719
I see you are rowdy today.
Behave yourself.  I beg you.
This thread is *so* not worth highjacking.
314554 tn?1337457719

I'm ok if you're ok
If I write back (which I am going to regret the moment I click on "Submit")
..and you respond: the post is highjacked.
It is up to you to be the bigger man
233616 tn?1312790796
there are several thread in here dealing with iron absorption which are more complete.

the thing to remember is that most HCV patients are high in iron, and on treatment can become dangerously high. This excess iron is stored primarily in the liver and other vital areas where it can go great harm. Iron is though to be the chief oxidizer responsible for the high rates of liver cancer (HCC) in HCV patients.

therefore is would be best to revisit some of threads that concentrate on inhibiting iron absorption and tracking ones own blood levels. This is one of the few proactive things we can do to prevent the onset of liver cancer, now the 5th largest killer of men in the USA.

233616 tn?1312790796
one example amongst several good ones

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