Caffeine worsens insulin resistance in prediabetics

[CoWriter]

Interestingly, a study showed that when diabetics had caffeine equivalent to four cups of coffee, their average daily blood sugar levels rose 8 per cent.  On the other hand, pre-diabetics (fasting blood sugar higher than 100) had the equivalent to 3 cups of coffee and three hours later, their blood sugar increased by 15 percent and the insulin production by 18 percent.  So pre-diabetics may not see a big increase in their blood sugar, but the hyperinsulinemia is getting worse.  And as we know, hyperinsulinemia makes interferon ineffective.

Co


Caffeine worsens insulin resistance in prediabetics.
Family Practice News
April 15 2007

WASHINGTON -- Caffeine intake appears to exaggerate post-meal insulin resistance in prediabetic adults who regularly drink several cups of coffee each day, according to preliminary results of a randomized, double-blind, crossover study of 50 individuals.

The results "suggest that caffeine consumption promotes the development of type 2 diabetes in those people who are at greatest risk for this disease," James D. Lane, Ph.D., said at the annual meeting of the Society of Behavioral Medicine.

This is the first time that caffeine's effects on insulin resistance have been measured in habitual coffee drinkers with prediabetes, said Dr. Lane of the department of psychiatry and behavioral medicine at Duke University, Durham, N.C. More than 12 other studies have shown that caffeine administration acutely raises insulin resistance both in healthy, nondiabetic volunteers and in patients with type 2 diabetes.

Other studies have shown that coffee drinking is associated with a significantly reduced risk of type 2 diabetes, but these conclusions have been "based on correlational observations, not controlled, experimental studies," he noted.
In the current study, all participants had prediabetes (average impaired fasting blood glucose level of 111 mg/dL) and drank at least 2 cups of coffee per day, which was confirmed by a 7-day food diary. Each person fasted overnight and did not consume any caffeine, which preserved any tolerance that they had developed from their continued exposure to caffeine.

On the first day of testing, the participants received either 250 mg caffeine or placebo pills and had their fasting blood glucose levels measured. On the second day, they received the opposite of what they had taken on day 1. After 60 minutes, they had their blood glucose levels measured again, and they received a booster dose of 125 mg caffeine or placebo. They also drank a BoostPlus liquid meal replacement shake (75 g carbohydrates, plus fat and protein), which is similar to an oral glucose tolerance test except that it is more like a real meal, Dr. Lane said. Blood samples were drawn during each of the next 3 hours.

The total 375-mg dose of caffeine was equivalent to about 3 cups of brewed coffee, similar to what subjects consumed on average each day (409 mg).

For the first 41 participants with full results available, caffeine increased the 3-hour area under the curve (AUC) for plasma glucose by 15% more than placebo, though the result was not statistically significant. But the 3-hour AUC for plasma insulin was 18% greater with caffeine than with placebo--a significant difference. AUC is the standard method for measuring responses to oral glucose tolerance tests, said Dr. Lane. "'This pattern of results shows that caffeine did increase insulin resistance in these prediabetic subjects."

A normal response to the extra insulin produced with caffeine would have been to reduce the peak glucose level to a point lower than what was seen with placebo. But "'the glucose response was, if anything, a little larger in the caffeine condition," he said. "Given the conditions of our study, we think that this insulin resistance effect occurs every day as these prediabetic individuals and others like them consume caffeinated beverages in the real world."

[CoWriter]

"forgot to mention exercise "
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Exercise every time you drink coffee.....great idea Jim!  Think they'll do it?

Co

[CoWriter]

"mixing decaf with regular getting to half and half mix"
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That's a great way of doing it.  You should be very proud of yourself for all the positive changes you've made to your lifestyle.  


"Cigarettes tried the Champix pills  almost made me ready for the loney bin"
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CS and I tried to tell you.  But maybe we didn't say enough bad things about it.  We'll have to do better next time...LOL


"Next I will have to go to church"
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I won't be promoting that....unless I see studies that show it increases SVR.

Co

[CoWriter]

"One thing that I recall was being told by the NP that I should reduce my coffee intake during the trial.  I believe that the jist I discerned was that it was thought to diminish response rates."
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Many of the Study Coordinators are Hep C speakers...so they would promote decreasing caffeine intake to prevent dehydration, is my guess.  

But putting it on the inclusion criteria and listing an amount (two 8-ounce cups) is very interesting.  Maybe they know something we don't know.  I wonder if it's on the Telaprevir and Boceprevir consents.  Maybe somebody will jump in and tell us what they were told when they enrolled.

Thanks for pointing that out Willy.  It's made me very curious, of course.  

Co

[jmjm530]

I thought you could do better than that :)

However you twist it, diet and exercise are the first line defense against IR per accepted protocols. If you continue to fail to mention it, I will continue to. :) And btw eating "protein" with the orange will not help much. You would have to eat an adequate amount of fat as well with the orange to slow down the sugar absorption.

-- Jim

[jmjm530]

To paraphrase "HR" on similar discussions on nutrition. While he does strongly advocate selective supplements, he still maintains that the protective pyramid is based on smart lifestyle choices such as proper diet, exercise, weight control, etc. My problem is not with valuable information you provice re the IR drugs , but that you tend skip over the base of the pyramid, and jump right into the drugs. Like much in life, there is no free lunch and unfortunately sometimes heavy lifting (i.e. diet, exercise and weight loss) are sometimes called for. To simply say, as you have in the past, that it's too difficult is to give up before you begin.

-- Jim

[lapis]

Nope, nothing in Tela trial consent about coffee!