Hi I have been searching since I saw your question. I can find the Sogo and the Sime but not the Daclatisvir.
I tried searching on the forum and only came up with your question.
I then tried to google it, again only came up with the first two together either with or without riba.
I will keep searching
Dee
Hi, I did find this, I hope it helps
http://www.journal-of-hepatology.eu/article/S0168-8278%2814%2900305-5/pdf
thanks dee i found it helpfull so that is the treatment my dr has got in store for me start n bout 2 weeks so i will keep forum updated
thanks
geo
just got date to start now
Sofosbuvir
Simpriver
Interfern
12 weeks and start on wed so hope i can kick some hep c ***
Did I understand you right that they are going to put you back on Interferon? That seems crazy!
Especially when Sovaldi/Ledisprevir combo is up for approval Oct 10th - tested mostly for hepc1s, but I have heard some success with others. I understand from some posts on the Forum that Gilead is geared up to start delivery as soon as approval is given.
Also, Daclatasvir from Bristol Meyers Squibb should be considered sometime in Movember. This one has to be taken with Sovaldi - not as convient as a 1 pill wonder, BUT it was being tested on those who have failed treatment/relapsed, cirrhotics, and those (like me) who are hepc 3. Again, from what I have read on their site and on bms.com/new, and by simply entering daclatasvir trials in the box, this should be effective on 1s, 2s, 3s, and, I believe 4s. I have not read anything about 5s and 6s on that site. This combo of 1 daclatasvir (called Daklinza there) has been approved for treatment in Europe. That same brand name may be used here, but I have not seen anything definitive.
Finally AbbVie is up for consideration for approval in December? I think. I am not up on whether it is a 1 pill combo or not and which sub genotypes it has been tested on.
If you are cirrhotic, Interferon is contraindicated. If you have treated with it before, it is contraindicated, or did I misunderstand you? Have you ever treated with INF before? What is your genotype?
Sorry, didn't mean to go off like that, but I am worried that with all these new meds coming out soon, your Dr is putting you on INF.
Tell me to go climb a tree, if I am out in left field. Good treating, no matter what, and I wish you SVR this time!
OOPS! Forgot to finish the statement on Daklinzaq: that should read: "this combo of 1 DAKLINZA AND 1 SOVALDI per day has been approved in Europe for treatment. That came from the bms.com/news site - a news article listed there.
Sorry, Pat
yes they r treating me with interferon again with sobosvir simpriver was on ribavarin and interferon for 48 weeks so dont know why they changed there mind with interferon thanks for your reply
geo
and im gt 3a and cirhotic cheers
Hello, You are on a winning combination therapy, I would be shocked if you did not clear the virus by Week 4, even earlier is quite possible. Even if your starting viral titer is in the millions of IU/ml. INF ( Interferon) is on its' way out, and quickly. Soon to be followed by Ribavirin (RBV). I'm not sure how long your tx period is, but I'm sure your chances of a permanent SVR ( sustained viral response, a.k.a virus free forever) is > 95%. Congratulations on getting access to these drugs, I hope you did not bankrupt yourself to affodr them. Please keep us posted, and good luck.... mac790
PLEASE talk to your Dr - or better yet - call a transplant center. I Think that being cirrhotic really should disqualify you from the INF.
Maybe I am wrong. We need input from some of our cirrhotic treaters, or post transplant posters.
The Daclatasvir is what my Dr and I have discussed if I fail on this 24 week treatment with Sovaldi (400 mg 1 x day), and Ribavirin (6 200 mg capsules - 3 in am and 3 in pm). As I told you before, I am hepc 3, too.
Good luck, whicever way you go. Pat
Forgot to say I treated w/ Interferon for 7 months in 94/95 - back when that was used by itself - 3 injections a week gor the 7 months, which is why my Dr was able to get Ins Co to approve the Sol/Riba first time.
P
thanks for ur input everyone but im actually in the uk and we get treated on the nhs so cost is nothing just wish everyone had that option as debating what treatment u get because of cost is not right in my point of view interferon is going to be 135 ml and course is 12 weeks thanks
geo
thanks for ur input everyone but im actually in the uk and we get treated on the nhs so cost is nothing just wish everyone had that option as debating what treatment u get buecause of cost is not right in my point of view interferon is going to be 135 ml and course is 12 weeks thanks
geo
A totally different story! You do what you have to do.
Good luck and I wish you SVR this time!!! Pat
It's my understanding that they treat 3a's with Solvadi/Riba these days. Interferon is being pulled off the shelves and lawsuits abound due to lasting damage from it.
That is what I am seeing from posts on here, from my own experience and from what I hearing in my Drs office - at least those Dr is not waiting to treat w/Sovaldi and Daclatasvir after approval (assuming it is approved here AND the Insurance Cos will approve it, off label. Pat
well started treatment again today ( hurrah )
on 12 weeks of ribavarin 400 in morning and 600 in evening
also sofosbuvir 400 in morning so heres hoping i win this battle
thanks everyone fore your information
geo
hi everyone thanks for your advice well im 4 weeks into riba / sofo n more dilemas lol ive put another post about it day i started got bloods virus was <12 done bloods 2 weeks in to treatment and virus is undetected so dr reckons 12 eot was positive but i might have cleared the virus as its very rare but can happen hence <12 so riba has been reduced to 200 in morn and 200 at night and sofo in morning dr wants mri scan cause bloods have went haywire but albumin was rising ang platletts higest they have ever been at 74 billiruben rose high but goin down so looks good but think dr is little bit stumped so any advice would b brill n thanks for all your words of advice and comfort really is a brill forum
thanks
geo
hi forum hope everyones ok . Seen my dr yesterday and they say lot of strange things been happening so they are sebding my last 5 bloods to a geneticist ( what the f--- ) apart from that everything seems ok any ideas
thanks
geo
Hi there, I am glad you are treating.
As far as geneticist, I remember another member here who's hepatologist had tested him saying that different backgrounds could get different results from various tx's
I am not really up on this stuff but I remember himtalking about taking his blood and he tested for Northern European so his tx would be based on that. It was interesting as he did not know his back ground. Evidently there have been studies on this.
It is amazing what they can find out.
I hope these tests will help you.
So...are you taking the medications you listed above or did it change?
Sofosbuvir
Simepriver
Daclatisvir
Take Care :)
Hi I wanted to come back to ask how you are feeling? I hope you are handling the tx well. Some people have problems, others don't the best news is that it is only 12 weeks so much less time than the old 48 to 72 weeks.
Take Care
hi dee thannks for reply and hope u r ok dr decided on sofo/riba for 24 weeks and sides r non existent compared to riba/interferon . been on this tx for 5 weeks and think this is where mystery lies 12 EOT Riba/Interferon detectec waited a few month started Sofo/Riba bloods took day i started and virus was <12 2 weeks into treatment undetected so its inbetween txs what happened did i cure etc etc
thanks
geo
Geo
I started Tx with a viral load of 357. Cleared in 2 weeks. Am now cured.
I think your immune system may have cleared this virus on its own with a little help from your prior Tx.
We do know that up to 25% of infected persons can clear the virus on there own. I do believe that's whats happening to you.
When I was first detected my viral # was 56. My Hepa said my body was fighting the virus trying to cure itself. We decided to treat and knock it out for good. And we did.
Hope that's whats happening to you. Think it is!
....Kim
Geo
There was another person on here that had there Bili go haywire while on Tx.
It was a rare condition but stabilized once Tx ended. Can't remember who it was but hopefully they will read this and respond. Know it was one of the guys on here. Think his Bili went to a 7, but not positive. There was a name for this condition and its very rare.
....Kim