Check this Out

[Rockerforlife]

This protese inhibitor trial i am signed up for is not the Vertex one..its the Boceprevir Phase II Study ....anyone out there know anything on this.,,,here s a liink to some news on it...looks really good


http://findarticles.com/p/articles/mi_m4PRN/is_2008_August_4/ai_n27967944

[can-do-man]

In this comment.....Wondering if telaprevir has results also for non-responders to compare with?

I should have added, close to the SAME conditions has the above bocprevir study for non-responders.

[can-do-man]

Thanks, link wouldn't work but found this...
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Boceprevir in Null Responders

The results from another study using boceprevir in combination with PegIntron plus ribavirin yielded less promising outcomes.  However, this trial was more about establishing the most effective dose of boceprevir, treatment duration, safety issues and if ribavirin was needed to maximize treatment response rates.  

In the study there were 357 genotype 1 patients enrolled who were deemed prior null responders – defined as either less than a 2 log10 drop in HCV RNA after 12 weeks of therapy with pegylated interferon/ribavirin therapy or who did not achieve undetectable HCV RNA if treated longer than 12 weeks.  There were 7 arms in this study – with or without different doses of boceprevir (100, 200, 400, 800 mg), and with and without ribavirin. This study had a lead-in phase using PegIntron alone.    

  

Bottom Line

It is hard to draw any concrete conclusions because of the small patient population and the many different treatment arms.  The group of patients in this study are some of the most difficult to treat and most did not receive the most effective dose of boceprevir.  The newly announced phase 3 studies will hopefully answer the question of the role of boceprevir in the retreatment of prior non-responders
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Wondering if telaprevir has results also for non-responders to compare with? Also in the above study couldn't find how many weeks of tx,  Also no riba in some arms, different doses of boceprevir, lead-in with Pegintron only, and 7 ARMS, plus a big difference in non-responders and relapsers. I just don't think one can take much out of this.

cando

[cindyh113]

My little my mind can't get around all that! Must be the riba.Thank God you can. I'm happy for you and will be praying you kick its butt. If I don't clear I will need your experience.
Cindy

[Rockerforlife]

it would be nice to do 72 weeks SOC with the PI....if i didn get SVR then...i would pack it in...untill then..."the fight must go on."...Freddie Mercury

[CoWriter]

So you're a relapser....and that gives you a better chance of clearing than a non-responder.  If the virus responded before, it should respond again.  But you're right, you may need 72 weeks.  

[Marcia2202]

So you are not a non responder, partial responder, nor null responder....

You are a relapser...

I think you should follow your feeling... If you don't want to take the risk of ending up in the placebo arm and thus having done 48 for nothing... If your doc is agreeing to treat aggressively and you think he is a good doc... why not hook up with him instead?

Whatever you decide... I'm backing you with whatever support I can give, my friend.

Marcia