Aa
Direct-acting Drugs Danoprevir plus RG7128 Suppress HCV without Interferon
While this still hasn’t been ‘SVR proven’, the preliminary 5 log-10 reduction at 14 days looks very interesting; more in the article from the hivandhepatitis site:
“SUMMARY: Results from the INFORM-1 trial, which evaluated 2 experimental agents that target different steps of the hepatitis C virus (HCV) lifecycle, showed that a combination of direct-acting drugs can suppress viral replication without interferon or ribavirin. As described in the October 14, 2010 advance online edition of The Lancet, the HCV protease inhibitor danoprevir (RG7227 or ITMN-191) plus the polymerase inhibitor RG7128 reduced HCV RNA by about 5 logs in both treatment-naive and previously treated patients, and caused no serious side effects in this 14-day study.”
http://www.hivandhepatitis.com/hep_c/news/2010/1022_2010_a.html
--Bill
“SUMMARY: Results from the INFORM-1 trial, which evaluated 2 experimental agents that target different steps of the hepatitis C virus (HCV) lifecycle, showed that a combination of direct-acting drugs can suppress viral replication without interferon or ribavirin. As described in the October 14, 2010 advance online edition of The Lancet, the HCV protease inhibitor danoprevir (RG7227 or ITMN-191) plus the polymerase inhibitor RG7128 reduced HCV RNA by about 5 logs in both treatment-naive and previously treated patients, and caused no serious side effects in this 14-day study.”
http://www.hivandhepatitis.com/hep_c/news/2010/1022_2010_a.html
--Bill
Well. Good on Scotland. I'm guessing they're not predominantly Geno 1 in Scotland.
http://www.hepcscotland.co.uk/home.aspx
A new campaign has been launched by the Scottish Government to raise awareness of Hepatitis C amongst the public in Scotland. The campaign seeks to make people aware of Hepatitis C as a cause of liver disease, the type of activities that put people at risk of catching the virus, and that treatment is available in Scotland which can cure up to 80% of those infected.
A separate campaign has also been launched to raise awareness of Hepatitis C amongst doctors, nurses and other health professionals who may come into contact with people living with the virus but unaware they are infected. The aim of this campaign is to ensure that as many people as possible at risk from Hepatitis C are offered a test and, if positive, treated for the virus.
The awareness campaigns are part of the Scottish Government's Hepatitis C Action Plan for Scotland.
http://www.hepcscotland.co.uk/home.aspx
A new campaign has been launched by the Scottish Government to raise awareness of Hepatitis C amongst the public in Scotland. The campaign seeks to make people aware of Hepatitis C as a cause of liver disease, the type of activities that put people at risk of catching the virus, and that treatment is available in Scotland which can cure up to 80% of those infected.
A separate campaign has also been launched to raise awareness of Hepatitis C amongst doctors, nurses and other health professionals who may come into contact with people living with the virus but unaware they are infected. The aim of this campaign is to ensure that as many people as possible at risk from Hepatitis C are offered a test and, if positive, treated for the virus.
The awareness campaigns are part of the Scottish Government's Hepatitis C Action Plan for Scotland.
Also the fact that it takes us so damn long to die from hcv makes it "appear" less urgent, although from the transplant numbers, liver cancer numbers, and deaths from liver disease we know it anything but. It's also not less urgent to those who are at or close to the end of the line, and more of us have had it longer and are getting sicker.
The perception by some uninformed people that HIV was a gay disease is also what politicized it and in a strange way eventually created the cohesiveness that caused the HIV community to act and push the government to respond, a lot in the name of discrimination.
The conservative right forced people to take a position, and the government was forced to deal with the accusations of discrimination, and the world suddenly had the horrible reality reality of HIV in their faces.
The HCV community lacks any cohesive force except the fact that we are all infected, you would think that would be enough, but apparently not.
The conservative right forced people to take a position, and the government was forced to deal with the accusations of discrimination, and the world suddenly had the horrible reality reality of HIV in their faces.
The HCV community lacks any cohesive force except the fact that we are all infected, you would think that would be enough, but apparently not.
"Boy do I disagree with that. HIV is an every man's disease? Right, sure it is. "
I did not say it IS an everyman's disease. What I said was:
"HIV/AIDS was also able to make it an everyman's disease. "
And what I meant were the organizations working with HIV/AIDS. There is a book called "The Wisdom of ******" by Elisabeth Pisano and it's an interesting read. It explains how they had to manipulate the system to get funding and how they had to sell HIV/AIDS to be able to do it because nobody, including the U.S., wanted to donate money for what was perceived to be a gay person's disease only. And it isn't in Africa and other parts of the world where sexual practices make it much more a hetersexual disease.
What they did was package HIV/AIDS in such a way that they could get funding. I do believe Hep C will have the same challenge. The few times that the topic has come up on Hep C in either of the national newspapers here in Canada, the subsequent discussion on the associated news forums generally has a tone of unwillingness to help people who brought this on themselves, which is what HIV/AIDS faced in the early days, I believe. I think that will be one of the challenges of Hep C as well.
I did not say it IS an everyman's disease. What I said was:
"HIV/AIDS was also able to make it an everyman's disease. "
And what I meant were the organizations working with HIV/AIDS. There is a book called "The Wisdom of ******" by Elisabeth Pisano and it's an interesting read. It explains how they had to manipulate the system to get funding and how they had to sell HIV/AIDS to be able to do it because nobody, including the U.S., wanted to donate money for what was perceived to be a gay person's disease only. And it isn't in Africa and other parts of the world where sexual practices make it much more a hetersexual disease.
What they did was package HIV/AIDS in such a way that they could get funding. I do believe Hep C will have the same challenge. The few times that the topic has come up on Hep C in either of the national newspapers here in Canada, the subsequent discussion on the associated news forums generally has a tone of unwillingness to help people who brought this on themselves, which is what HIV/AIDS faced in the early days, I believe. I think that will be one of the challenges of Hep C as well.
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