Feel free to use this thread for anything

[Magnum]

I know how difficulot it is to get a thread going. So go ahead and use this one...

Magnum

[jmjm530]

So in effect, by pre-dosing, the higher serum riba levels at day one could conceivably have the same effect -- or better -- than using very high initial doses of ribavirin -- without the severe sides -- that have already been shown to be effective at least in the Sweedish Pilot study. All speculation at this point but very exciting, at least to me, the riba obsessive I've been. :)

-- Jim

[jmjm530]

Yes, riba is not effective alone, however I'm assuming this new study will examine if peg therapy starting with higher initial serum riba levels (by pre-dosing riba by one month) will positively affect EVR and SVR. I think they might be onto something but let's see how the study plays out. Keep in mind that the normal protocol starts riba the same day as the Peg, however maxmium serum riba levels are not reached for 2-4 weeks.

-- Jim

[cuteus]

welcome to the forum, feel free to ask all these wonderful people anything.  One thing that is common here, is the desire to ease someone's burden a little.

[friole]

I am getting lost on the threads but this is in response to getting the larger syringes with the 1" needle. They gave me those for my first shot.  I was supposed to have the prefilled syringes, but the pharmacist did not know how to read the rx and gave me the vials.  The syringe had a 1" 22 gauge needle.  Like you said -- for a horse!  I got different needles after that.  I think the 1" are for intermuscular shots and are way too long for you.  Consider doing it in two shots if you can't get smaller needles.
frijole

[NYgirl]

I'm with FLGuy that's my week as well (Fri - Fri).

As a non-trial I started the Ribas in the morning and the shot at night all on the same day.  I remember calling to ask if the Ribas would make me sick. Wow to be so naive at one point it's almost like we go on Tx Overload. Sometimes I think we know too much and examine EVERYTHING far more than needed...but it's what seems to keep us SANE so it's worth it!

[jmjm530]

Can you share with us what trial your in? I often thought on a conceptual level that starting riba 2-4 weeks before the first shot would make a lot of sense. Especially in light of recent studies showing how important serum riba levels are to both early and later viral response. Also, what genotype are you? What dose of riba did they put you on? How much do you weigh? Thanks.

-- Jim