G-3 relapsed after 24 weeks of sovaldi + RBV

[geno333]

I have genotype 3, and was excited about treatment with sovaldi + RBV for 24 weeks. Sadly, I relapsed right after treatment ended, with a viral count of 7 million. What are my options now? Looks like there might be a chance if I repeat treatment for 12 weeks but add PEG this time .. although that's not specifically outlined in the AASLD recommendations (they only address retreatment when PEG fails, but say nothing about when sovaldi fails), so I'm afraid the insurance company won't go for it. Any ideas or experiences? Thank you!

[Jazmine6]

Wow I had pretty much given up hope on Harvoni but I'm going to definitely bring it up to my doctor now.  Fingers crossed for everyone with G3 also.

[BobA4]

Recently finished Solvaidi wth Ribivirin 24 weeks. Also had isolated Cirrhosis .genotype is 3-a. I let the hep c go to long and about 25% of the liver is hardened. I relapsed with a viral load of 4.3 million. I feel ok doing my daily routine but for how long?

[Drewmich]

What did the doctor you saw say about  geno 3's who achieve SVR12.  Whats the chance of relapse after that?  Thats the boat I'm in.  Do you or anybody out there know of anybody (G3) relapsing after getting an SVR12.

Thanks,
Andy S.

[AWorriedMom]

I am so sorry to hear about your relapse. I'm sure you are aware that with these new drugs genotype 3 patients are more likely to relapse than patients with genotype 1, 2, or 4. I attended a talk by Dr. Ira Jacobson tonight. He is a hepatologist at Cornell. He said the biggest problem now is what to do with geno 3 relapsers. I do not think Viekira is the way to go. Talk to,your doc about Harvoni and Ribavirin for 24 weeks. Even though it is not approved for relapsers some people have had their insurance companies pay for it. Hang in there....so many things are happening so fast something is sure to help soon.

[Livelife777]

Geno.  Wow I'm really so sorry that you relapsed esp after 24 weeks.  As Pooh has said, it wasn't the water and it wasn't your fault.
Won't reiterate the good advice you've been given but will say that Interferon is NOT the way to go.  With all the new meds coming out the Pharma Co are engaged in a battlefield and willing to bend somewhat for a piece of the action. I do believe a good Hepatologist will be able to help you maneuver thru the landlmines and find a working solution.
I do believe also that you should move quickly.  As previously said, you don't want or need to slip into the Cirrhotic Catagory with all its complications and implications.
I rather like the Duke idea.  I traveled 3 hours to see my Hepatologist without question.  It was so worth the effort and outcome.
Wish you well
.....Kim

[Jake571]

Hi geno,

I'm sorry it took so long to get back to you! I should have pointed out to you in my last comment that I have compensated cirrhosis and that I'm working with a transplant center who recommended  Harvoni plus Ribavirin for 24 weeks for GT-3. I previously have failed  Sovaldi plus Ribavirin 24 weeks and also Interferon and Ribavirin 24 weeks.They told me that it is being used in Europe. It was not an issue getting it approved by my insurance company. Best of luck to you! I hope this treatment becomes an option for you!