Gilead Trial with Sofosbuvir & GS-5816

[mdudley]

Gilead Sciences:  Twelve week Phase 2 trial of sofosbuvir + GS-5816 (without ribavirin or interferon) for genotypes 1, 2, and 3 treatment-naïve.

The Protocol Number:  GS-US-342-0102
Clinical Trial Number:  NCT01858766

Anyone else in the Gilead 12-week trial with sofosbuvir & GS-5816 (without ribavirin or interferon)?  The initial enrollment was 140 patients and I would like to connect with or hear from anyone else who may be in these trials.  Thanks!

[caz77777]

Does anyone else feel as if their whole body is in a constant state of tension, like a sustained adrenalin rush? I feel as if my eyes are on stalks and I am wired as if I am off to an exam or something? It's exhausting, I think this is similar to what Frannie felt with the muscle flickers, it's like hyper motor tension...anyone else?

[caz77777]

Hi Kerso, good to meet you! I seem to be getting increasingly tired too, just beginning week 9 here in Devon, started 29th September in Plymouth. My main side effect is being wired and spaced, as if my head is rushing with too much coffee/adrenalin. It's exhausting. A few fleeting headaches but nothing too bad. I am on the double blind too.

[Kerso]

Hi, I am on the double blind Astral 1 trial in Scotland. Started on 15th Sep so I only have 2 weeks left. I am pretty certain that I am on the treatment though and not the placebo. I had mild sore heads every day for the first month or so but they have become less frequent. I did have one today however. I am taking bit longer to get off to sleep at night even though I am really tired. The tiredness has been the main side effect but it is manageable compared to my previous treatment attempts. This is attempt number 3.

[caz77777]

Amazing news Woodeye!! I am at week 8 now and my enzymes are still hanging around 30-40, was so hoping to have a drop! They have dropped a tiny bit, but they were normal in the beginning... They have told me if I am on the drug and it's not working they would have stopped tx by now, and I know I am not on placebo, too many changes for that...so...let's all get well for 2015!! Happy Solstice everyone..keep on keeping on x

[jenn1958]

That is fantastic news Woodeye, very happy for you!  Can I ask what sort of back pain you had early on?  I had some upper back pain which now seems to be improving as I'm just reaching week 4.  Merry Christmas to all!

[Woodeye1]

Greetings all!

I hope everyone is improving as we go down this road. Wanted to wish you all the best of the holidays and also provide a little more hope if I can, so, Merry Christmas, Happy Holidays and best for the new year.

As a personal update, after 35 days of treatment (42% elapsed) I just received my latest numbers:

Starting ALT 209.    New ALT 21
Starting AST 166.   New AST 23

Very exciting! Keep the faith. We're all going to be cured!

Best to all!