Gilead Trial with Sofosbuvir & GS-5816

[mdudley]

Gilead Sciences:  Twelve week Phase 2 trial of sofosbuvir + GS-5816 (without ribavirin or interferon) for genotypes 1, 2, and 3 treatment-naïve.

The Protocol Number:  GS-US-342-0102
Clinical Trial Number:  NCT01858766

Anyone else in the Gilead 12-week trial with sofosbuvir & GS-5816 (without ribavirin or interferon)?  The initial enrollment was 140 patients and I would like to connect with or hear from anyone else who may be in these trials.  Thanks!

[theskier]

Cindy, that is great news. How is your husband feeling now that we are 6 months down the road? Yes I agree that this 1 pill program is phenomonal but my liver is on overload now more than ever. I am just hoping it is just working on getting rid of the gnarly power pill and it just takes longer when the liver is compensated......

[Cindy815]

My husband was in a phase 3 trial with Sofosbuvir/GS5816 for patients with cirrhosis.  He just received his 12 week post treatment results - Undetected.  This is an amazing treatment.  I hope it is FDA approved soon.    

[theskier]

That is really encouraging you are feeling better Jenn. Interesting you have had to pick sleep position in the past. Mine demands to lie on stomach or right side. My liver flame is tuning down a bit today but still total weak and fatigue . Last night soaked sheets and pillow from internal heat. I had these feelings several years ago but not at all lately. I can only conclude that my liver is still trying to detox the medicine. Did you originally ever get really sick when you were 17? Did you have symptoms most of your life. Did you drink during your life? My doc warned me in 1972 no drink, no tylenol if you want to live long. I obeyed but I did enjoy pie cookies ice cream etc.... which was like adding to the fatty liver problem while hep c was pacmaning. I am being really careful now more than ever as I would like to feel better. I am frustrated that we can not find the rest of the 600 from our trial as well as the trial 1 and 2 patients to hear how they are doing. That would be so helpful. Take care and wishing you continued improvement.

[jenn1958]

Hi Skier, we were right on the same schedule as I started a day before you. I had a F1-F2 fibroscan score the year before I started the trial.  I must say that I did not feel tired and wired while on the drugs.  I did feel a little "off" for the first week and I had a metallic taste in my mouth for the first few days.  I felt really tired and I slept a lot during the first two weeks post treatment and I started to feel all kinds of sensations around the liver region, don't know if I would describe it as burning but it was really worrying.  Over the years I have attributed a lot of "symptoms" that I have had to hep C but one thing that has changed without a doubt is something I had never associated with my liver.  Since I was about 19 I noticed that I couldn't lie flat on my back for long periods of time without getting pain in my right shoulder and down my arm.  About a month ago I noticed that I was lying on my back with no pain and I have tested it almost everyday since then and I have no pain at all when lying on my back.  Other than that I do seem to have more stamina.

[theskier]

Hi stronglady, Its been some time since you completed your treatment. How are you doing now?

[theskier]

Jenn congrats on the healing proccess. How do you feel now. We started the trial similar  time and I  completed in  jan. 12. I began with liver at stage f4. How was your liver prior and now. About 2 weeks ago my liver region turned into a flame and I do not feel well . I do not take any medicine /alcohol and eat well so I am curious whats going on. I was called Thurs  by trial group and told I had the real deal which was obvious as alt 257 , ast 191 on 10/31/2014.  As of 12/11 2014,  alt 26, ast 27. Hope you are doing well.