I'd be interested in anything you have regarding problems with ARBs.
Regarding your ACE:
(1) What strength did you try and was it suggested to titrate up ?
(2) Any side effects
(3) Did it bring down your systolic and how much?
(4) Have you tried diuretics either with it, or alone? I've read a diuretic can amplify the effects of the ACE but maybe it's just additive.
Of course it your ACE isn't doing its job then you have to change, what will be your next drug of choice?
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Dear Co:
I hope BB has a chance to read your post and then discusses the betablocker with his doctor, who prescribed it to be taken during tx. There may be a valid reason for this class of drug during tx but the NP is likely unaware of the IR risk. I'd love to hear back from BB about the doctor's reason. Maybe it's a balancing act. (Please don't laugh.)
I know beta-blockers are out of fashion, except under the table for performance anxiety, so thank you very much for sending me great information that confirms this. Still, it's important to say again that my mom took it successfully for at least thirty years. She didn't develop diabetes or have cardiac events.
Jim:
My ACE may be a beauty of a drug by all accounts but it ain't bringing down my isolated diastolic during tx. Nonetheless, I love what I read about the 'magic' ACE and don't mind taking it. I prefer it to an ARB, which hasn't been studied as long. There was some very bad press about it recently (I'm linkless today) in combination with ACE.
I briefly had a dry cough but nobody who's done tx would likely give it a second thought. It was tolerable and temporary.
Rocker:
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Yes, somewhat the opposite in the U.S. where diuretics have received recent press with study backing as the most effective first-line rx treatment for high bp. For example, my internist suggest hydrochlorothiazide to start with, that being a very common diuretic. On the other hand, my cardio likes the Ace Inhibitors to start. And to add to the confusion, my tx doc liked the combo treatments like Hyzzar which combine the angiotensin II receptor Losartan with the diruetic hydrochlorothiazide.
All this left me one very confused guy :) and lately I've been experimenting with both losartan and hydrochlorothiazide either solo or in combination to see what actually works as no sense taking a combo like Hyzaar if one drug is simply going along for a free ride without benefit. I have yet to try an Ace Inhibitor but hear they have more side effects (dry throat and coughing for example) than an angiotensin II receptor like Cozaar.
Any more suggestions here would be welcome because while I'm confused, maybe if I get more confused I will then see some clarity.
-- Jim
"Beta-blockers fell out of favor and had bad press, even though my mom took it successfully for years. Somehow, it makes sense to me that how it dilates the arteries and slows down the heart would be a perfect match with the side effects of tx. My doc loves ace inhibitors but I think she may be missing something."
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Actually, beta-blockers and diuretics increase a patient's risk of developing DIABETES. while ACE inhibitors and Angiotensin Receptor Blockers decrease the risk of diabetes. Clinical guidelines in Great Britain, (but not the US), call for avoiding diuretics and beta-blockers as first-line treatment of hypertension due to the risk of diabetes.
http://en.wikipedia.org/wiki/Beta_blocker
I certainly wouldn't want to try a beta blocker during treatment when developing IR/Diabetes can make you fail.
Do you know what Metformin, ACE inhibitors, and statins have in common? They're anti-oxidants. That's why all of them can prevent diabetes.
This is one of my favorite articles. Yes, I have lots of favorites...LOL
"Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited"
http://atvb.ahajournals.org/cgi/content/full/24/5/816
Co
Sorry, my bad. Micardis is an ARB. Someone who is on it recently told me it's a beta-blocker but I just looked it up.
Nice that it's working for you.